ArticleMolecular cell2021
HRD1-mediated METTL14 degradation regulates m
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Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
48 citing papers in PubMed, 70 citations in OpenAlex.
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- p62/SQSTM1-KEAP1 complex prevents clearance of ubiquitinated Z alpha-1 antitrypsin and aggravates liver proteotoxicity.The Journal of biological chemistry · 2026Article
- Dual regulation of the unfolded protein response by IGF2BP3 during ER stress.Genes & development · 2026Article
- METTL14-dependent NExperimental & molecular medicine · 2026Article
- GDPPH1 induces cell cycle arrest by downregulation of CDK4/Cyclin D1 via the mCell death & disease · 2026Article
- RNA modification-mediated multidimensional crosstalk: a novel perspective on gene expression regulation.Genome biology · 2026Review
- ENDOU-1-induced cytoplasmic HnRNPA3 recognizes m6A methylation on the upstream reading frame of human CHOP transcripts to achieve maximal CHOP translation.Cellular and molecular life sciences : CMLS · 2026Article
- Loss of METTL14 in dopaminergic neurons disrupts ER homeostasis via m6A-dependent regulation of Atp2a3 mRNA: Implications for Parkinson's Disease.NPJ Parkinson's disease · 2026Article
- METTL16-mediated mJournal of experimental & clinical cancer research : CR · 2026Article
- ER Proteotoxic Stress Drives Mitochondrial Dysfunction in Heat-Stressed Intestinal Epithelial Cells.Cells · 2026Article
- The role of ER-associated degradation and ER-phagy in health and disease.Signal transduction and targeted therapy · 2026Review
- Endoplasmic reticulum stress in Hashimoto's thyroiditis: a candidate amplification node linking thyroid-specific vulnerability and immune dysregulation.Frontiers in immunology · 2026Review
- Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review).Molecular medicine reports · 2025Review
- mAmerican journal of physiology. Gastrointestinal and liver physiology · 2025Article
- YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- RNA Modifications in Health and Disease.MedComm · 2025Review
- SEL1L regulates ER homeostasis in Sertoli cells but is dispensable for their function.Molecular biology of the cell · 2025Article
- METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response.FEBS open bio · 2025Article
- Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy.Trends in cell biology · 2025Review
- SEL1L-HRD1-mediated ERAD in mammals.Nature cell biology · 2025Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Juncheng WeiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: juncheng.wei@northwestern.edu.
Bryan T HaradaDepartment of Chemistry and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
Dan LuDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Ruihua MaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Beixue GaoDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Yanan XuDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Elena MontautiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Nikita ManiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Shuvam M ChaudhuriDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Shana GregoryDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Samuel E WeinbergDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Donna D ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Richard GreenDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Chuan HeDepartment of Chemistry and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
Deyu FangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: fangd@northwestern.edu.
Northwestern University · USHoward Hughes Medical Institute · USUniversity of Arizona · US
Funding
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MNRF Transcription Factors in Environmental Stress and Disease InterventionR35ES031575 · NIEHS · UNIVERSITY OF FLORIDA · PI Donna D Zhang · 2020 to 2026
$7.1MTRAINING IN METABOLISM, DIABETES AND ENDOCRINOLOGYT32DK007169 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Joseph Bass · 1988 to 2026
$6.6MNovel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9MClinical analysis and therapeutic development of exosomal ACE2R01AI167272 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Deyu Fang, Huiping Liu · 2022 to 2026
$3.6MA deubiquitination module controls Treg adaptation to tumor microenvironmentR01CA257520 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU, ZHANG, BIN · 2021 to 2025
$2.8MCholestasis and the Unfolded Protein ResponseR01DK093807 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREEN, RICHARD M · 2012 to 2020
$2.8MRegulation of Rhythmic m6A RNA Modification by ER‐associated DegradationR01DK126908 · NIDDK · WAYNE STATE UNIVERSITY · PI FANG, DEYU, ZHANG, KEZHONG · 2021 to 2024
$2.2MTargeting a Treg deubiquitinase in antitumor immune therapyR01CA232347 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU · 2018 to 2022
$1.7MThe Unfolded Protein Response in Fatty LiverR01DK121997 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREEN, RICHARD M · 2019 to 2022
$1.6MRole of m6A modification in Alpha 1-antitrypsin deficiency induces liver diseaseR21HD104904 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI WEI, JUNCHENG · 2021 to 2022
$415kThe role of mRNA methylation in the progression of endometrial cancerF32CA221007 · NCI · UNIVERSITY OF CHICAGO · PI HARADA, BRYAN TSUTOMU · 2017 to 2019
$179kHoward Hughes Medical InstituteNCI NIH HHS F32 CA221007NCI NIH HHS R01 CA232347NCI NIH HHS R01 CA257520NHGRI NIH HHS RM1 HG008935NIAID NIH HHS R01 AI167272NICHD NIH HHS R21 HD104904NIDDK NIH HHS R01 DK093807NIDDK NIH HHS R01 DK120330NIDDK NIH HHS R01 DK121997NIDDK NIH HHS R01 DK126908NIDDK NIH HHS T32 DK007169NIEHS NIH HHS R35 ES031575
Abstract
Accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen triggers an unfolded protein response (UPR) for stress adaptation, the failure of which induces cell apoptosis and tissue/organ damage. The molecular switches underlying how the UPR selects for stress adaptation over apoptosis remain unknown. Here, we discovered that accumulation of unfolded/misfolded proteins selectively induces N
Indexed as
Endoplasmic Reticulum-Associated DegradationEndoplasmic Reticulum StressAdeninealpha 1-Antitrypsinalpha 1-Antitrypsin DeficiencyAnimalsApoptosisDisease Models, AnimalEndoplasmic ReticulumHEK293 CellsHep G2 CellsHumansLiverLiver DiseasesMethyltransferasesMice6-methyladenineAdeninealpha 1-AntitrypsinDDIT3 protein, humanDdit3 protein, mouseMethyltransferasesMETTL14 protein, humanMettl14 protein, mouseSERPINA1 protein, humanSYVN1 protein, humanSyvn1 protein, mouseTranscription Factor CHOPUbiquitin-Protein Ligases
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