Evidence map›Paper›PMID 34846916›Full record

ArticleJCO oncology practice2022

Global Risk Indicator and Therapy for Older Patients With Diffuse Large B-Cell Lymphoma: A Population-Based Study.

Mengyang Di, Tamra Keeney, Emmanuelle Belanger, Orestis A Panagiotou, Adam J Olszewski

Abstract read
In one paragraph

Article in JCO oncology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengyang DiDepartment of Medicine, Alpert Medical School of Brown University, Providence, RI.ORCID 0000-0001-6165-2617
Tamra KeeneyMongan Institute, Center for Aging and Serious Illness, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-2603-8707
Emmanuelle BelangerMongan Institute, Center for Aging and Serious Illness, Massachusetts General Hospital, Boston, MA.ORCID 0000-0001-7301-0451
Orestis A PanagiotouMongan Institute, Center for Aging and Serious Illness, Massachusetts General Hospital, Boston, MA.ORCID 0000-0001-9604-8380
Adam J OlszewskiDepartment of Medicine, Alpert Medical School of Brown University, Providence, RI.ORCID 0000-0002-6472-6658

Funding

ECOG-ACRIN NCORP Research Base - TMISTUG1CA189828 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$199.7M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
VARIATIONS IN LIFE'S FINAL CHAPTERP01AG027296 · NIA · BROWN UNIVERSITY · PI AMAL N. TRIVEDI · 2007 to 2026
$38.9M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
National Research Service AwardT32HS000011 · AHRQ · BROWN UNIVERSITY · PI TRIVEDI, AMAL N. · 1986 to 2024
$6.1M
Which Post-Acute Care Setting is Best for Patients' Outcomes?R01AG054656 · NIA · BROWN UNIVERSITY · PI GOZALO, PEDRO L, GRABOWSKI, DAVID C · 2017 to 2019
$1.7M
AHRQ HHS T32 HS000011NCATS NIH HHS UL1 TR001863NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS UG1 CA189828NIA NIH HHS P01 AG027296NIA NIH HHS R01 AG054656
6 · The paper itself

Abstract

purposeTo examine the impact of global risk, a measure comprising age, comorbidities, function, and cognitive statuses, on treatment selection and outcomes among older home care recipients with diffuse large B-cell lymphoma.

methodsFrom SEER-Medicare, we selected home care recipients diagnosed with diffuse large B-cell lymphoma in 2011-2015, who had pretreatment Outcome and Assessment Information Set (OASIS) evaluations. We created a global risk indicator categorizing patients as low-, moderate-, or high-risk on the basis of OASIS assessments. We examined the association of global risk with receipt of therapy and among chemotherapy recipients, with mortality, emergency department visits, hospitalization, and intensive care unit admission within 30 days from first treatment in logistic models, reporting adjusted odds ratios (OR) with 95% CI. We compared overall survival across risk groups estimating adjusted hazard ratios.

resultsOf the 1,232 patients (median age, 80 years), 65% received chemotherapy. High-risk patients (

conclusionGlobal risk on the basis of OASIS is easily available, suggesting a potential way to improve patient selection for curative treatment and institution of preventive measures.

Indexed as

Lymphoma, Large B-Cell, DiffuseMedicareAgedAged, 80 and overHumansIntensive Care UnitsProportional Hazards ModelsRisk FactorsUnited States

Identifiers

PMID34846916
PMCPMC8932488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.