ArticleCirculation2021
Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 67 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Polygenic prediction of preeclampsia and gestational hypertension.Nature medicine · 2023Pooled it
- On-treatment platelet reactivity through the thromboxane AJournal of thrombosis and thrombolysis · 2023Trial
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- Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- A tri-omics and machine learning framework identifies prognostic biomarkers and metabolic signatures in sepsis.Scientific reports · 2026Article
- Neutrophils and NETosis in polycystic ovary syndrome: unraveling the immuno-metabolic thromboinflammatory axis.European journal of medical research · 2026Review
- Porphyromonas gingivalis-derived outer membrane vesicles promote vascular endothelial glycocalyx injury via the PPAD/CitH3/B3GAT1 pathway.Journal of nanobiotechnology · 2026Article
- Bimodal regulation and precision therapy of neutrophil extracellular traps in liver ischemia-reperfusion injury: recent advances.Frontiers in immunology · 2026Review
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- Neuromodulation and Copper Chelation Reverse Sleep Fragmentation-Aggravated Myocardial Ischemia-Reperfusion Injury by Targeting NET-Induced Endothelial Cuproptosis.Research (Washington, D.C.) · 2026Article
- Neutrophil Extracellular Traps in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Targets.Journal of inflammation research · 2026Review
- Neutrophil death pathways in myocardial infarction: the balance between injury and repair.Frontiers in immunology · 2026Review
- Structural Insights into Recognition and Translocation of Oxidized Phospholipid by CD36 Using Mass Spectrometry, Molecular Docking, Dynamics, and Metadynamics Simulations.Journal of the American Chemical Society · 2025Article
- Inhibiting Monocyte Migration Reduces Arterial Thrombosis and Facilitates Thrombolysis.Stroke · 2025Article
- Macrophage DNases Limit Neutrophil Extracellular Trap-Mediated Defective Efferocytosis in Atherosclerosis.Circulation research · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 6 institutions in 2 countries.
Huijuan DouMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).
Andriana KotiniDepartment of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (A.K., M.O., E.P.P.).ORCID 0000-0001-9148-6015
Wenli LiuMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).ORCID 0000-0002-1981-611X
Trevor FidlerMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).
Kaori Endo-UmedaMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).ORCID 0000-0002-4012-4353
Xiaoli SunDepartment of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.).
Malgorzata OlszewskaDepartment of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (A.K., M.O., E.P.P.).
Tong XiaoMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).ORCID 0000-0003-1462-4650
Sandra AbramowiczMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).
Mustafa YalcinkayaMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).
Brian HardawayMolecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).
Sotirios TsimikasDepartment of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.).ORCID 0000-0001-9834-9494
Xuchu QueDepartment of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.).ORCID 0000-0002-6751-5493
Alexander BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (A.B.).ORCID 0000-0001-5824-9595
Conor EmdinCardiovascular Research Center, Massachusetts General Hospital, Boston (C.E., P.N.).ORCID 0000-0002-2385-8259
Pradeep NatarajanCardiovascular Research Center, Massachusetts General Hospital, Boston (C.E., P.N.).ORCID 0000-0001-8402-7435
Eirini P PapapetrouDepartment of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York (A.K., M.O., E.P.P.).
Joseph L WitztumDepartment of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.).ORCID 0000-0002-5195-6614
Nan Wang *Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).ORCID 0000-0001-9976-0859
Alan R Tall *Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.).
Columbia University Irving Medical Center · USXenobe Research Institute · USIcahn School of Medicine at Mount Sinai · USBroad Institute · USNihon University · JPVanderbilt University Medical Center · US
Funding
Clonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MJAK2V617F, clonal hematopoiesis and atherosclerosisR01HL148071 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAN WANG · 2019 to 2026
$4.0MClonal hematopoiesis, inflammasomes and atherosclerosisR01HL155431 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2021 to 2026
$3.7MMechanisms linking LNK genetic variation to atherothrombosisR01HL137663 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TALL, ALAN RICHARD · 2017 to 2020
$2.0MHDL, platelet progenitors, atherosclerosis and thrombosisR01HL118567 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, NAN · 2014 to 2018
$2.0MMalondialdehyde-induced Endothelial Dysfunction in AtherosclerosisR00HL148504 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SUN, XIAOLI · 2021 to 2023
$747kMalondialdehyde-induced Endothelial Dysfunction in AtherosclerosisK99HL148504 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIAOLI · 2020 to 2020
$160kAmerican Heart Association-American Stroke Association 20POST35210454 - HUIJUAN DOUBritish Heart Foundation CH/1996001/9454Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHLBI NIH HHS K99 HL148504NHLBI NIH HHS R00 HL148504NHLBI NIH HHS R01 HL118567NHLBI NIH HHS R01 HL137663NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148071NHLBI NIH HHS R01 HL155431
Abstract
backgroundLNK/SH2B3 inhibits Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling by hematopoietic cytokine receptors. Genome-wide association studies have shown association of a common single nucleotide polymorphism in
methodsWe bred mice with combined deficiency of
results
conclusionsHematopoietic
Indexed as
Platelet AggregationAdaptor Proteins, Signal TransducingAnimalsArteriesBlood PlateletsMiceMice, KnockoutNeutrophilsOxidation-ReductionPhospholipidsThrombosisAdaptor Proteins, Signal TransducingLnk protein, mousePhospholipidsclonal hematopoiesiscoronary artery diseaseextracellular trapsphospholipidsthrombosis
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.