Evidence map›Paper›PMID 34846845›Full record

ArticleACS applied materials & interfaces2021

Effect of Nanoparticle Synthetic Conditions on Ligand Coating Integrity and Subsequent Nano-Biointeractions.

Jessica C Hsu, Yu Du, Arjun Sengupta, Yuxi C Dong, Katherine J Mossburg, Mathilde Bouché, Andrew D A Maidment, Aalim M Weljie, David P Cormode

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Atomically-precise AuJournal of nanobiotechnology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jessica C HsuDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, Pennsylvania 19104, United States.ORCID https://orcid.org/0000-0002-3599-2834
Yu DuDivision of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Arjun SenguptaDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Yuxi C DongDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, Pennsylvania 19104, United States.ORCID https://orcid.org/0000-0001-7739-3795
Katherine J MossburgDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, Pennsylvania 19104, United States.
Mathilde BouchéDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, Pennsylvania 19104, United States.ORCID https://orcid.org/0000-0003-2707-1290
Andrew D A MaidmentDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, Pennsylvania 19104, United States.
Aalim M WeljieDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
David P CormodeDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, Pennsylvania 19104, United States.ORCID https://orcid.org/0000-0002-8391-9500
University of Pennsylvania · USTranslational Therapeutics (United States) · US

Funding

Nanoparticle contrast agents for earlier breast cancer detectionR01CA227142 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2018 to 2022
$2.5M
NCI NIH HHS R01 CA227142
6 · The paper itself

Abstract

Most current nanoparticle formulations have relatively low clearance efficiency, which may hamper their likelihood for clinical translation. Herein, we sought to compare the clearance and cellular distribution profiles between sub-5 nm, renally-excretable silver sulfide nanoparticles (Ag

Indexed as

AnimalsCoated Materials, BiocompatibleFemaleLigandsLiverMaterials TestingMiceMice, NudeNanoparticlesParticle SizeSilver CompoundsTomography, X-Ray ComputedCoated Materials, BiocompatibleLigandsSilver Compoundssilver sulfidehepatic cellsmicrofluidicsnanoparticlesrenal clearancesilver sulfide

Identifiers

PMID34846845
PMCPMC8715381
OpenAlexW3214948058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.