ArticleJournal of assisted reproduction and genetics2021
Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases.
Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Gonadotropin-resistant ovary syndrome in a hypergonadotropic patient withJCEM case reports · 2026Article
- Treatment of human oocytes with extracellular vesicles from follicular fluid during rescueHuman reproduction open · 2026Article
- Infertility management in resistant ovary syndrome: a review.Frontiers in endocrinology · 2025Review
- Cumulative live birth rate after oocyte in vitro maturation with a pre-maturation step in women with polycystic ovary syndrome or high antral follicle count.Journal of assisted reproduction and genetics · 2023Article
- Application value of Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol in patients with resistant ovary syndrome.BMC pregnancy and childbirth · 2023Article
- Resistant ovary syndrome: Pathogenesis and management strategies.Frontiers in medicine · 2022Review
- Human oocyte capacitation culture: Essential step toward hormone-free assisted reproductive technology.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGonadotropin-resistant ovary syndrome (GROS) is a rare endocrine disorder that causes hypergonadotropic hypogonadism, amenorrhea, and infertility. This study reports live birth in two women with GROS who underwent fertility treatment with in vitro maturation (IVM).
methodsBoth patients had primary infertility, amenorrhea (primary and secondary), typical secondary sexual characters, elevated gonadotropin levels, normal ovarian reserve, normal chromosomal characteristics, and previous nonresponsiveness gonadotropin stimulations. One patient had polymorphism of the follicle-stimulating hormone receptor, which is a predictor of poor ovarian response. Given unresponsiveness to exogenous gonadotropin stimulations, IVM with human chorionic gonadotropin priming (hCG-IVM) was performed in both patients. All transferrable embryos were vitrified.
resultsBoth patients achieved pregnancy after their first frozen embryos transfer, and each delivered a healthy baby boy.
conclusionsThese results suggest that IVM should be a first-line therapeutic option for patients with GROS.
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Registered trials
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