ReviewBrain structure & function2022
Establishing the functional relevancy of white matter connections in the visual system and beyond.
Review in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Postnatal maturation of putamen microstructure accompanies topographic white matter connectivity and altered circuits in autism.bioRxiv : the preprint server for biology · 2026Article
- Eye Movement Impairment in Women Undergoing Chemotherapy.Journal of eye movement research · 2025Article
- White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity and category-selectivity from birth.Nature human behaviour · 2025Article
- Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.Brain : a journal of neurology · 2025Article
- White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity, and category-selectivity from birth.bioRxiv : the preprint server for biology · 2025Article
- Fusion of 3D photorealistic lateral-to-medial brain white matter dissection and diffusion tensor imaging for dynamic visualization of key fiber tracts.Brain & spine · 2025Article
- Tractometry of Human Visual White Matter Pathways in Health and Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Differences in educational opportunity predict white matter development.Developmental cognitive neuroscience · 2024Article
- Article
- A practical guide for combining functional regions of interest and white matter bundles.Frontiers in neuroscience · 2024Article
- Improved prediction of glioma-related aphasia by diffusion MRI metrics, machine learning, and automated fiber bundle segmentation.Human brain mapping · 2023Article
- Functional and Structural Properties of Interhemispheric Interaction between Bilateral Precentral Hand Motor Regions in a Top Wheelchair Racing Paralympian.Brain sciences · 2023Article
- A role for the fornix in temporal sequence memory.The European journal of neuroscience · 2023Article
- White matter connections of high-level visual areas predict cytoarchitecture better than category-selectivity in childhood, but not adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Fiber-specific structural properties relate to reading skills in children and adolescents.eLife · 2022Article
- Understanding structure-function relationships in the mammalian visual system: part two.Brain structure & function · 2022Article
- Hyperconnectivity in resting-state fMRI as a marker of disease severity in Myotonic Dystrophy Type 1.Journal of neuromuscular diseasesArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
For over a century, researchers have examined the functional relevancy of white matter bundles. Consequently, many large-scale bundles spanning several centimeters have been associated in their entirety with specific brain functions, such as language or attention. However, these coarse structural-functional relationships are at odds with modern understanding of the fine-grained functional organization of human cortex, such as the mosaic of category-selective regions in ventral temporal cortex. Here, we review a multimodal approach that combines fMRI to define functional regions of interest within individual's brains with dMRI tractography to identify the white matter bundles of the same individual. Combining these data allows to determine which subsets of streamlines within a white matter bundle connect to specific functional regions in each individual. That is, this approach identifies the functionally defined white matter sub-bundles of the brain. We argue that this approach not only enhances the accuracy of interpreting the functional relevancy of white matter bundles, but also enables segmentation of these large-scale bundles into meaningful functional units, which can then be linked to behavior with enhanced precision. Importantly, this approach has the potential for making new discoveries of the fine-grained functional relevancy of white matter connections in the visual system and the brain more broadly, akin to the flurry of research that has identified functional regions in cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.