ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022
Sarcopenia in patients with dementia: correlation of temporalis muscle thickness with appendicular muscle mass.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Meta-analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Predictive Value of Temporal Muscle Thickness for Sarcopenia after Acute Stroke in Older Patients.Nutrients · 2022Trial
- Temporalis Muscle Thickness as a Prognostic Marker in Acute Ischemic Stroke: A Systematic Review.Journal of clinical medicine · 2026Review
- Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife.Journal of Alzheimer's disease : JAD · 2026Article
- Sarcopenia in cognitive disorders: Toward a shared pathophysiological framework.Osteoporosis and sarcopenia · 2026Review
- Integrated Analysis of Cerebral Small Vessel Disease and Facial Soft-Tissue Markers in the Alzheimer's Disease Continuum.Brain sciences · 2026Article
- Soft tissue changes in Dementia: A comprehensive systematic review.Aging brain · 2026Review
- Evaluation of temporal muscle thickness in subjects with acromegaly: a follow-up study.Therapeutic advances in endocrinology and metabolism · 2026Article
- TissUnet: Improved extracranial tissue and cranium segmentation for children through adulthood.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Association of temporal and masseter muscle thickness with cognitive function and clinical severity in Alzheimer's disease: a retrospective study.Frontiers in neuroscience · 2026Article
- The primary hospitals should take gait speed as a routine test for elderly patients.Scientific reports · 2025Article
- Association of temporalis muscle thickness and frailty in an Australian memory clinic cohort.Aging clinical and experimental research · 2025Article
- Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- A Comprehensive Review of the Correlations of Measurement Parameters among Modern Technologies for Sarcopenia Assessment.Aging and disease · 2025Review
- Empowering Data Sharing in Neuroscience: A Deep Learning Deidentification Method for Pediatric Brain MRIs.AJNR. American journal of neuroradiology · 2025Article
- Article
- Temporal Muscle Thickness and Sarcopenia Components in Healthy Adults, Validated through Allgeun Diagnostic Tool.Healthcare (Basel, Switzerland) · 2024Article
- The prevalence and co-existence of geriatric syndromes in older patients with dementia compared to those without dementia.Aging clinical and experimental research · 2024Article
- Sarcopenia and anti-seizure medication response in juvenile myoclonic epilepsy.Brain and behavior · 2024Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cognitive decline is one of the most relevant signs of sarcopenia; however, it is challenging to perform tests for sarcopenia in patients with dementia. In a recent study, temporalis muscle thickness (TMT), an alternative to appendicular muscle mass (ASM), was found to be a valid index for screening sarcopenia. This study aimed to determine whether TMT correlates with ASM and evaluate the relationship between TMT and cognitive function in dementia patients. We recruited patients with a complaint of memory loss who visited the Memory Clinic of Konkuk University Medical Center between November 2014 and December 2020. Patients with probable Alzheimer's disease (AD) without weakness were included. TMT was measured on axial T1-weighted magnetic resonance (MR) images, perpendicular to the long axis of the temporal muscle, at the orbital roof level. ASM was measured using body dual-energy X-ray absorptiometry (DXA). It was calculated as the sum of lean soft tissue mass in the arms and legs, and the value by ASM divided by height squared was used. Inter-rater reliability and intra-rater reliability were good and excellent, respectively. We found a correlation between TMT and skeletal ASM, which was obtained from cranial MR images and DXA, respectively (r = 0.379, p = 0.001). TMT was negatively correlated with age (r = - 0.296, p = 0.014) and positively correlated with body mass index (BMI) (r = 0.303, p = 0.012). Additionally, TMT was correlated with MMSE (r = 0.350, p = 0.003). After adjusting for educational years, there was still a correlation between TMT and MMSE (r = 0.256, p = 0.038). This study demonstrated that TMT correlates with ASM and cognitive function in patients with dementia. Measuring TMT using cranial MR images could help diagnose sarcopenia accessibly and assess cognitive function in patients with dementia.
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