Evidence map›Paper›PMID 34846541›Full record

ArticleAnalytical and bioanalytical chemistry2022

Development of single- and multiplex immunoassays for rapid detection and quantitation of amodiaquine in ACT drugs and rat serum.

Jingqi Qian, Mian Wang, Zhaoxiang Wang, Rui Feng, Jiaqi Zhang, Chencheng Ye, Man Zhang, Baomin Wang, Liwang Cui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jingqi Qian *College of Agriculture and Biotechnology, China Agricultural University, Beijing, 100193, China.
Mian Wang *College of Food and Bioengineering, Xihua University, Chengdu, 610039, Sichuan, China.
Zhaoxiang WangCollege of Biological and Sciences, China Agricultural University, Beijing, 100193, China.
Rui FengCollege of Agriculture and Biotechnology, China Agricultural University, Beijing, 100193, China.
Jiaqi ZhangCollege of Agriculture and Biotechnology, China Agricultural University, Beijing, 100193, China.
Chencheng YeCollege of Agriculture and Biotechnology, China Agricultural University, Beijing, 100193, China.
Man ZhangCollege of Agriculture and Biotechnology, China Agricultural University, Beijing, 100193, China.
Baomin WangCollege of Agriculture and Biotechnology, China Agricultural University, Beijing, 100193, China. wbaomin@263.net.
Liwang CuiDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, FL, 33612, USA. liwangcui@usf.edu.
China Agricultural University · CNUniversity of South Florida · USXihua University · CN

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
NIAID NIH HHS U19 AI089672
6 · The paper itself

Abstract

Amodiaquine (AQ) is a commonly used antimalarial drug, and N-desethyl-AQ (N-DEAQ) is an active metabolite of AQ. Given the significance of drug quality in the management of malaria cases, this study aims to develop antibody-based assays for the detection and quantitation of AQ without the need for sophisticated equipment. Two monoclonal antibodies (mAbs) against AQ, designated as JUN7 and TE7, were selected, which showed 72.7% and 9.5% cross-reactivity to N-DEAQ, respectively. These mAbs showed <0.1% cross-reactivity to other commonly used antimalarial drugs. An indirect competitive enzyme-linked immunosorbent assay (icELISA) based on JUN7 showed a 50% inhibitory concentration (IC

Indexed as

AmodiaquineAnimalsAntibodies, ImmobilizedAntibodies, MonoclonalAntimalarialsEnzyme-Linked Immunosorbent AssayFemaleMiceMice, Inbred BALB CRatsTime FactorsAmodiaquineAntibodies, ImmobilizedAntibodies, MonoclonalAntimalarialsAmodiaquineAntimalarial drugDrug qualityImmunoassayN-desethyl-amodiaquinePharmacokinetic

Identifiers

PMID34846541
PMCPMC9475496
OpenAlexW3216206515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.