Evidence map›Paper›PMID 34846301›Full record

ArticleeLife2021

The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice.

Cristina Segalin, Jalani Williams, Tomomi Karigo, May Hui, Moriel Zelikowsky, Jennifer J Sun, Pietro Perona, David J Anderson, Ann Kennedy

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it, 221 citations in OpenAlex.

  1. Pooled it
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  13. FERAL: A Video-Understanding System for Direct Video-to-Behavior Mapping.bioRxiv : the preprint server for biology · 2025
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Cristina SegalinDepartment of Computing & Mathematical Sciences, California Institute of Technology, Pasadena, United States.ORCID 0000-0001-7219-7074
Jalani WilliamsDepartment of Computing & Mathematical Sciences, California Institute of Technology, Pasadena, United States.
Tomomi KarigoDivision of Biology and Biological Engineering 156-29, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, United States.
May HuiDivision of Biology and Biological Engineering 156-29, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-6231-7383
Moriel ZelikowskyDivision of Biology and Biological Engineering 156-29, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-0465-9027
Jennifer J SunDepartment of Computing & Mathematical Sciences, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-0906-6589
Pietro PeronaDepartment of Computing & Mathematical Sciences, California Institute of Technology, Pasadena, United States.
David J AndersonDivision of Biology and Biological Engineering 156-29, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, United States.ORCID 0000-0001-6175-3872
Ann KennedyDivision of Biology and Biological Engineering 156-29, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-3782-0518
California Institute of Technology · US

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7M
Region-Specific, Inducible Axonal Tract-Tracing in the BrainR01MH070053 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI David J Anderson · 2004 to 2026
$9.7M
Circuit basis of social behavior decision-making in a subcortical networkR01NS123916 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSON, DAVID J · 2021 to 2025
$2.9M
Prefrontal Circuit Control of Isolation-Induced AggressionR01MH132822 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Moriel Zelikowsky · 2023 to 2026
$2.3M
Multimodal, integrated analysis of neural activity and naturalistic social behavior in freely moving miceR01MH123612 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSON, DAVID J, PERONA, PIETRO · 2020 to 2024
$2.1M
Genetic dissection of neural circuits underlying trauma, fear, and social behaviorR00MH108734 · NIMH · UNIVERSITY OF UTAH · PI ZELIKOWSKY, MORIEL · 2019 to 2021
$747k
Modeling a Neural Circuit for Flexible Control of Innate BehaviorsR00MH117264 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KENNEDY, ANN KATHRYN · 2021 to 2023
$742k
Modeling a neural circuit for flexible control of innate behaviorsK99MH117264 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KENNEDY, ANN KATHRYN · 2019 to 2020
$222k
Genetic dissection of neural circuits underlying trauma, fear, and social behaviorK99MH108734 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ZELIKOWSKY, MORIEL · 2016 to 2017
$182k
Howard Hughes Medical InstituteNIMH NIH HHS K99 MH108734NIMH NIH HHS K99 MH117264NIMH NIH HHS R00 MH108734NIMH NIH HHS R00 MH117264NIMH NIH HHS R01 MH070053NIMH NIH HHS R01 MH123612NIMH NIH HHS R01 MH132822NIMH NIH HHS U19 MH114830NINDS NIH HHS R01 NS123916
6 · The paper itself

Abstract

The study of naturalistic social behavior requires quantification of animals' interactions. This is generally done through manual annotation-a highly time-consuming and tedious process. Recent advances in computer vision enable tracking the pose (posture) of freely behaving animals. However, automatically and accurately classifying complex social behaviors remains technically challenging. We introduce the Mouse Action Recognition System (MARS), an automated pipeline for pose estimation and behavior quantification in pairs of freely interacting mice. We compare MARS's annotations to human annotations and find that MARS's pose estimation and behavior classification achieve human-level performance. We also release the pose and annotation datasets used to train MARS to serve as community benchmarks and resources. Finally, we introduce the Behavior Ensemble and Neural Trajectory Observatory (BENTO), a graphical user interface for analysis of multimodal neuroscience datasets. Together, MARS and BENTO provide an end-to-end pipeline for behavior data extraction and analysis in a package that is user-friendly and easily modifiable.

Indexed as

AlgorithmsSocial BehaviorSoftwareAnimalsBehavior, AnimalMicePattern Recognition, Automatedcomputer visionmachine learningmicroendoscopic imagingmouseneurosciencepose estimationsocial behaviorsoftware

Identifiers

PMID34846301
PMCPMC8631946
OpenAlexW3216930742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.