ArticleJournal of applied clinical medical physics2022
Varian ethos online adaptive radiotherapy for prostate cancer: Early results of contouring accuracy, treatment plan quality, and treatment time.
Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07245745 (Prospective Clinical Study Comparing Patient-reported Outcomes Measurements), which is not on this map. Cited by 138 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Clinical Study Comparing Patient-reported Outcomes Measurements (PROMS) After Adaptive or Conventional Radiotherapy in Prostate Cancer
Who cites it
138 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Joint EANM-SNMMI guideline on the role of 2-[European journal of nuclear medicine and molecular imaging · 2024Guideline
- Deep learning methods for enhancing cone-beam CT image quality toward adaptive radiation therapy: A systematic review.Medical physics · 2022Pooled it
- An in-house timer for ART-specific extra time in gynecologic pelvic online adaptive radiation therapy.Technical innovations & patient support in radiation oncology · 2026Article
- Improving deep learning organ segmentation accuracy in cone-beam CT-guided radiotherapy using a robust scatter suppression method.Physics and imaging in radiation oncology · 2026Article
- Optimizing the delivery of radiotherapy with artificial intelligence.Nature reviews. Clinical oncology · 2026Review
- Automated planning architectures for online adaptive radiotherapy: A narrative review of the ethos and unity/Monaco platforms.Journal of applied clinical medical physics · 2026Review
- Development of CBCT-Guided Online Adaptive Radiotherapy.Cancers · 2026Review
- Article
- Article
- Image-based evaluation of a commercial AI synthetic CT generator for brain and prostate MR-only radiotherapy.Journal of applied clinical medical physics · 2026Article
- Adaptive Radiotherapy in the Era of Image Guidance and Artificial Intelligence: A Critical Review.Cancers · 2026Review
- CBCT based online daily adaptive treatment improves target coverage with limited benefit for OAR protection in SBRT prostate cancer.Radiation oncology (London, England) · 2026Article
- MRI-enhanced online adaptive radiotherapy by virtual integration of a standalone MRI simulator and CBCT-based treatment delivery.Radiation oncology (London, England) · 2026Article
- Innovative radiotherapy approaches.ESMO gastrointestinal oncology · 2026Review
- FS-Mamba: Feature-wise scanning Mamba UNet for automatic image segmentation in liver tumor radiotherapy.Journal of applied clinical medical physics · 2026Article
- Development of a cost-effective end-to-end commissioning test for simulation-omitted direct-to-unit adaptive radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Synthetic CT generation from cone-beam CT using deep learning for head-and-neck adaptive radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Improved synthetic CT generation using surface scan information integrated into a deformable registration algorithm for limited Field of View data.Physics and imaging in radiation oncology · 2026Article
- Diagnostic CT-guided online adaptive radiotherapy for locally advanced colon cancer: a prospective implementation and feasibility study.Clinical and translational radiation oncology · 2026Article
- Artificial intelligence and transforming cancer care.Discover oncology · 2026Review
78 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Varian Ethos system allows for online adaptive treatments through the utilization of artificial intelligence (AI) and deformable image registration which automates large parts of the anatomical contouring and plan optimization process. In this study, treatments of intact prostate and prostate bed, with and without nodes, were simulated for 182 online adaptive fractions, and then a further 184 clinical fractions were delivered on the Ethos system. Frequency and magnitude of contour edits were recorded, as well as a range of plan quality metrics. From the fractions analyzed, 11% of AI generated contours, known as influencer contours, required no change, and 81% required minor edits in any given fraction. The frequency of target and noninfluencer organs at risk (OAR) contour editing varied substantially between different targets and noninfluencer OARs, although across all targets 72% of cases required no edits. The adaptive plan was the preference in 95% of fractions. The adaptive plan met more goals than the scheduled plan in 78% of fractions, while in 15% of fractions the number of goals met was the same. The online adaptive recontouring and replanning process was carried out in 19 min on average. Significant improvements in dosimetry are possible with the Ethos online adaptive system in prostate radiotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.