ArticleeLife2021
Control of parallel hippocampal output pathways by amygdalar long-range inhibition.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Proximity in mice induced by an auditory-conditioned stimulus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Affiliation in mice induced by an auditory-conditioned stimulus.bioRxiv : the preprint server for biology · 2026Article
- Review
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Article
- Fear Synchrony of Mouse Dyads: Interaction of Sex Composition and Stress.Biological psychiatry global open science · 2025Article
- Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats.Neurobiology of stress · 2025Article
- Hidden state inference requires abstract contextual representations in the ventral hippocampus.Science (New York, N.Y.) · 2024Article
- Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats.Neurobiology of stress · 2024Article
- Amygdala-hippocampus somatostatin interneuron beta-synchrony underlies a cross-species biomarker of emotional state.Neuron · 2024Article
- Internal-state-dependent control of feeding behavior via hippocampal ghrelin signaling.Neuron · 2024Article
- Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala.Science advances · 2023Article
- Linking external stimuli with internal drives: A role for the ventral hippocampus.Current opinion in neurobiology · 2022Review
- Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour.Nature communications · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons and avoids prefrontal cortex-projecting vH neurons, while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.