Evidence map›Paper›PMID 34845907›Full record

ArticleJournal of medicinal chemistry2021

New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of

Elisa Magli, Caterina Fattorusso, Marco Persico, Angela Corvino, Gianluca Esposito, Ferdinando Fiorino, Paolo Luciano, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino and 7 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elisa MagliDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Caterina FattorussoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Marco PersicoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Angela CorvinoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Gianluca EspositoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Ferdinando FiorinoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-7357-5751
Paolo LucianoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Elisa PerissuttiDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Vincenzo SantagadaDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Beatrice SeverinoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-3887-8869
Valentina TedeschiDepartment of Neuroscience, Division of Pharmacology, University of Naples "Federico II", via Pansini 5, 80131 Naples, Italy.
Anna PannaccioneDepartment of Neuroscience, Division of Pharmacology, University of Naples "Federico II", via Pansini 5, 80131 Naples, Italy.
Giuseppe PignataroDepartment of Neuroscience, Division of Pharmacology, University of Naples "Federico II", via Pansini 5, 80131 Naples, Italy.
Giuseppe CaliendoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Lucio AnnunziatoIRCCS SDN, via E. Gianturco 113, 80143 Naples, Italy.
Agnese SecondoDepartment of Neuroscience, Division of Pharmacology, University of Naples "Federico II", via Pansini 5, 80131 Naples, Italy.
Francesco FrecenteseDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-8821-2937

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the neuroprotective role of the Na

Indexed as

AnimalsBenzodiazepinonesDrug DesignNeuroprotective AgentsProtein IsoformsPyrrolidinesSodium-Calcium ExchangerStructure-Activity Relationship7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo(e)(1,4)diazepin-2(3H)-oneBenzodiazepinonesNeuroprotective AgentsProtein IsoformsPyrrolidinesSodium-Calcium Exchanger

Identifiers

PMID34845907
PMCPMC8713167

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.