ArticleCancer medicine2022
Incidence and relative risk of metachronous second primary cancers for 16 cancer sites, Osaka, Japan, 2000-2015: Population-based analysis.
Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis.Breast cancer research : BCR · 2023Pooled it
- Risk factors for metachronous esophageal squamous cell carcinoma after endoscopic or surgical resection of esophageal carcinoma: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Sequential changes in conditional survival of patients following surgical resection of colorectal cancer and indicators for follow-up beyond 5 years.International journal of clinical oncology · 2026Article
- Article
- Metachronous triple primary malignancies of duodenum, skin, and appendix in the absence of common hereditary syndromes: a case report.American journal of cancer research · 2026Article
- Subsequent primary cancer incidence in cervical cancer survivors: insights from a comprehensive cohort study utilizing combined Japanese population-based cancer registries.Journal of gynecologic oncology · 2026Article
- Sequential triple primary malignancies in the larynx, lung, and liver with discordant p53 expression patterns: a case report.American journal of cancer research · 2026Article
- Relative survival among cancer survivors enrolled in private cancer insurance in Japan, using the internal insurance-enrolled population as the reference.International journal of clinical oncology · 2025Review
- Effects of Parkinson's disease on survival in cancer survivors: a retrospective, multicentre cohort study in Japan.Brain communications · 2025Article
- Incidence and pattern of second primary cancer in patients diagnosed with primary cancer.Oncology letters · 2024Article
- Arterial Thromboembolism in Japanese Patients With Cancer: Incidence, Predictors, and Survival Impact.JACC. CardioOncology · 2024Article
- Heart Disease Mortality in Cancer Survivors: A Population-Based Study in Japan.Journal of the American Heart Association · 2023Article
- Analysis of the development of gastric cancer after resecting colorectal lesions using large-scale health insurance claims data.Journal of gastroenterology · 2023Article
- Nomograms constructed for predicting diagnosis and prognosis in cervical cancer patients with second primary malignancies: a SEER database analysis.Journal of cancer research and clinical oncology · 2023Article
- Hospital volume and prognosis of patients with metastatic pancreatic cancer: A study using the Osaka Cancer Registry.Journal of cancer research and clinical oncology · 2023Article
- Prognostic impact of the presence or absence of prior cancer in patients with cancer using cure models: A population-based study.Cancer science · 2023Article
- Providing Suggested Rules for Multiple Primary Cancer Recording, Coding and Registering in Population-based Cancer Registry.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Clinical characteristics and survival of glioblastoma complicated with non-central nervous system tumors.Chinese neurosurgical journal · 2022Article
- Incidence and relative risk of metachronous second primary cancers for 16 cancer sites, Osaka, Japan, 2000-2015: Population-based analysis.Cancer medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increasing number of cancer survivors have developed multiple primaries. This study aims to describe the incidence and risk patterns of metachronous second primary cancers (SPCs) in Osaka, Japan.
methodsData were obtained from the Osaka Cancer Registry, a population-based database of all cancers diagnosed in Osaka. The study subjects were individuals who were first diagnosed with invasive cancers in 16 major cancer sites during 2000-2014, aged 15-79 years, survived at least 3 months, and were followed up for 10 years. We measured incidence rates, cumulative risks, and standardized incidence ratios (SIRs: with the Osaka general population as the referent) of developing SPCs during 3 months to 10 years after the first diagnosis.
resultsDuring 2000-2015, among 418,791 cancer survivors, 24,368 (5.8%) developed SPCs within 10 years of first diagnosis. Males had higher incidence rates than females except among young-onset survivors (aged 15-39 years). 10-year cumulative risks among survivors aged 70-79 years (the most dominant age group) were 24.0% (male) and 11.8% (female). 10-year SIRs were 1.38 (95% CI, 1.36-1.40; male) and 1.44 (95% CI, 1.41-1.48; female) with higher estimates among younger survivors in both sexes. Strong bidirectional associations were observed between oral/pharyngeal, esophageal, and laryngeal cancers. Survivors of any smoking-related cancers had elevated SIRs of developing smoking-related SPCs. Similar results were observed for alcohol-related cancers.
conclusionsCancer survivors are at excess risk of developing SPCs compared to the general population. Continued surveillance is warranted to inform survivorship care through risk-based long-term care planning and lifestyle-changing efforts to prevent new cancers.
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