Evidence map›Paper›PMID 34845842›Full record

ArticleJournal of cellular and molecular medicine2022

Hyperpolarization-activated cyclic nucleotide-gated channels working as pacemaker channels in colonic interstitial cells of Cajal.

Seok Choi, Hyunhyo Seo, Kyungmin Lee, Dong Hoon Shin, Mei Jin Wu, Wenhao Wu, Xingyou Huang, Jingwei Zhang, Chansik Hong, Jae Yeoul Jun

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. The Functional Study of Prostaglandin EChonnam medical journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Seok ChoiDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.
Hyunhyo SeoDepartment of Anatomy, Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu, Korea.
Kyungmin LeeDepartment of Anatomy, Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu, Korea.
Dong Hoon ShinDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.
Mei Jin WuDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.
Wenhao WuDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.
Xingyou HuangDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.
Jingwei ZhangDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.
Chansik HongDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.ORCID 0000-0001-9684-4651
Jae Yeoul JunDepartment of Physiology, College of Medicine, Chosun University, Gwangju, Korea.ORCID 0000-0001-5391-5683
Chosun University · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels function as pacemaker channels in spontaneously active cells. We studied the existence of HCN channels and their functional roles in the interstitial cells of Cajal (ICC) from the mouse colon using electrophysiological, immunohistochemical and molecular techniques. HCN1 and HCN3 channels were detected in anoctamin-1 (Ca

Indexed as

Interstitial Cells of CajalAnimalsColonHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMiceHyperpolarization-Activated Cyclic Nucleotide-Gated Channelshyperpolarization-activated cyclic nucleotide-gated channelsinterstitial cells of Cajalpacemaker potential

Identifiers

PMID34845842
PMCPMC8743669
OpenAlexW3215184119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.