Evidence map›Paper›PMID 34845794›Full record

ArticleEuropean journal of neurology2022

Ischemic stroke in COVID-19 patients: Mechanisms, treatment, and outcomes in a consecutive Swiss Stroke Registry analysis.

Davide Strambo, Gian Marco De Marchis, Leo H Bonati, Marcel Arnold, Emmanuel Carrera, Santi Galletta, Krassen Nedeltchev, Timo Kahles, Carlo W Cereda, Giovanni Bianco and 28 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. COVID-19 independently predicts poor outcomes in Acute Ischemic Stroke- Insights from a multicenter study from Pakistan and United Arab Emirates.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 19 institutions in 2 countries.

Davide StramboStroke Center, Neurology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-4429-2714
Gian Marco De MarchisStroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0002-0342-9780
Leo H BonatiStroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID 0000-0003-1163-8133
Marcel ArnoldStroke Center, Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.ORCID 0000-0002-4274-4644
Emmanuel CarreraStroke Center, Geneva University Hospital, Geneva, Switzerland.ORCID 0000-0003-0045-5382
Santi GallettaStroke Center, Geneva University Hospital, Geneva, Switzerland.
Krassen NedeltchevStroke Center, Kantonsspital Aarau, Aarau, Switzerland.
Timo KahlesStroke Center, Kantonsspital Aarau, Aarau, Switzerland.
Carlo W CeredaStroke Center, Neurocenter of Southern Switzerland, Lugano, Switzerland.ORCID 0000-0002-6479-1476
Giovanni BiancoStroke Center, Neurocenter of Southern Switzerland, Lugano, Switzerland.
Georg KägiStroke Center, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Andreas R LuftStroke Center, University Hospital Zurich, Zurich, Switzerland.
Manuel BologneseStroke Center, Kantonsspital Lucerne, Lucerne, Switzerland.
Lehel-Barna LakatosStroke Center, Kantonsspital Lucerne, Lucerne, Switzerland.
Stephan SalmenStroke Unit, Spitalzentrum Biel, Biel, Switzerland.
Pamela CorreiaStroke Unit, Spitalzentrum Biel, Biel, Switzerland.
Rolf SturzeneggerStroke Unit, Kantonsspital Graubünden, Chur, Switzerland.
Albert SylvanStroke Unit, Kantonsspital Graubünden, Chur, Switzerland.
Friedrich MedlinStroke Unit, HFR Fribourg - Hôpital Cantonal, Fribourg, Switzerland.ORCID 0000-0002-8477-899X
Christian BergerStroke Unit, Cantonal Hospital of Grabs, Grabs, Switzerland.
Florian LindheimerStroke Unit, Cantonal Hospital of Grabs, Grabs, Switzerland.
Markus BaumgärtnerStroke Unit, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Ludwig ScheloskyStroke Unit, Kantonsspital Münsterlingen, Münsterlingen, Switzerland.
Christophe BonvinStroke Unit, Hôpital du Valais, Sion, Switzerland.
Marie-Luise MonoStroke Center, Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Biljana RodicStroke Unit, Kantonsspital Winterthur, Winterthur, Switzerland.
Andrea von RedingStroke Unit, Kantonsspital Winterthur, Winterthur, Switzerland.
Guido SchweglerStroke Unit, Stroke Unit, Spital Limmattal, Schlieren, Switzerland.
Federico MassiniStroke Unit, Stroke Unit, Spital Limmattal, Schlieren, Switzerland.
Alexander A TarnutzerStroke Unit, Cantonal Hospital of Baden, Baden, Switzerland.
Shadi TaheriStroke Center, Klinik Hirslanden, Zurich, Switzerland.
Nils PetersStroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Morin BeyelerStroke Center, Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Valerian AltersbergerStroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Stefan T EngelterStroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Urs FischerStroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Patrik MichelStroke Center, Neurology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-4954-7579
Swiss Stroke Registry Investigators
University of Basel · CHUniversity of Bern · CHKantonsspital Aarau · CHKantonsspital Graubünden · CHKantonsspital Münsterlingen · CHKantonsspital Winterthur · CHLaboratory for Biomedical Neurosciences · CHLuzerner Kantonsspital · CHProfessional Beef Services · USSpital Limmattal · CHSpitalzentrum Centre hospitalier Biel- Bienne · CHUniversity Hospital of Geneva · CHUniversity of Lausanne · CHFribourg Development Agency · CHHôpital du Valais · CHKantonsspital Baden · CHKantonsspital St. Gallen · CHKlinik Hirslanden · CHUniversity Hospital of Zurich · CH

Funding

Schweizerische Herzstiftung
6 · The paper itself

Abstract

backgroundMost case series of patients with ischemic stroke (IS) and COVID-19 are limited to selected centers or lack 3-month outcomes. The aim of this study was to describe the frequency, clinical and radiological features, and 3-month outcomes of patients with IS and COVID-19 in a nationwide stroke registry.

methodsFrom the Swiss Stroke Registry (SSR), we included all consecutive IS patients ≥18 years admitted to Swiss Stroke Centers or Stroke Units during the first wave of COVID-19 (25 February to 8 June 2020). We compared baseline features, etiology, and 3-month outcome of SARS-CoV-2 polymerase chain reaction-positive (PCR+) IS patients to SARS-CoV-2 PCR- and/or asymptomatic non-tested IS patients.

resultsOf the 2341 IS patients registered in the SSR during the study period, 36 (1.5%) had confirmed COVID-19 infection, of which 33 were within 1 month before or after stroke onset. In multivariate analysis, COVID+ patients had more lesions in multiple vascular territories (OR 2.35, 95% CI 1.08-5.14, p = 0.032) and fewer cryptogenic strokes (OR 0.37, 95% CI 0.14-0.99, p = 0.049). COVID-19 was judged the likely principal cause of stroke in 8 patients (24%), a contributing/triggering factor in 12 (36%), and likely not contributing to stroke in 13 patients (40%). There was a strong trend towards worse functional outcome in COVID+ patients after propensity score (PS) adjustment for age, stroke severity, and revascularization treatments (PS-adjusted common OR for shift towards higher modified Rankin Scale (mRS) = 1.85, 95% CI 0.96-3.58, p = 0.07).

conclusionsIn this nationwide analysis of consecutive ischemic strokes, concomitant COVID-19 was relatively rare. COVID+ patients more often had multi-territory stroke and less often cryptogenic stroke, and their 3-month functional outcome tended to be worse.

Indexed as

COVID-19Ischemic StrokeStrokeHumansRegistriesSARS-CoV-2SwitzerlandTreatment OutcomeCOVID-19ischemic strokeSARS-CoV-2

Identifiers

PMID34845794
PMCPMC9299927
OpenAlexW3214751863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.