Evidence map›Paper›PMID 34845731›Full record

ReviewJournal of medical virology2022

COVID-19 vaccinations: The unknowns, challenges, and hopes.

Kawthar Mohamed, Piotr Rzymski, Md Shahidul Islam, Rangarirai Makuku, Ayesha Mushtaq, Amjad Khan, Mariya Ivanovska, Sara A Makka, Fareeda Hashem, Leander Marquez and 14 more

Abstract readReview
In one paragraph

Review in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  20. Long-Term Autoimmune Polyarthritis due to COVID-19 Vaccine.HCA healthcare journal of medicine · 2025
    Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kawthar MohamedSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Piotr RzymskiDepartment of Environmental Medicine, Poznań University of Medical Sciences, Poznań, Poland.ORCID 0000-0002-4713-0801
Md Shahidul IslamDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Rangarirai MakukuSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ayesha MushtaqInternational Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan.
Amjad KhanDepartment of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.ORCID 0000-0002-6006-4159
Mariya IvanovskaDepartment of Microbiology and Immunology, Research Center, Medical University, Plovdiv, Bulgaria.
Sara A MakkaNeuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
Fareeda HashemSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Leander MarquezCollege of Social Sciences and Philosophy, University of the Philippines Diliman, Quezon City, Philippines.
Orsolya CseprekalDepartment of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
Igor Salerno FilgueirasDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Dennyson Leandro M FonsecaUniversal Scientific Education and Research Network (USERN), São Paulo, Brazil.
Essouma MickaelDepartment of Rheumatology and Physical Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Irene LingSchool of Science, Monash University Malasia, Jalan Lagoon Selatan, Darul Ehsan, Selangor, Malaysia.
Amanuel Godana AreroSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sarah CuschieriFaculty of Medicine and Surgery, University of Malta, Msida, Malta.
Kseniia MinakovaNational Technical University "Kharkiv Polytechnic Institute", Kharkiv, Ukraine.ORCID 0000-0002-8869-1082
Eduardo Rodríguez-RománCenter for Microbiology and Cell Biology, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Sunny O AbarikwuDepartment of Biochemistry, University of Port Harcourt, Choba, Nigeria.
Attig-Bahar FatenTunisia Polytechnic School, University of Carthage, Tunis, Tunisia.
Giulia GranciniDepartment of Chemistry, Physical Chemistry Unit, University of Pavia, Pavia, Italy.
Otavio Cabral-MarquesDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Nima RezaeiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-3836-1827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The entire world has been suffering from the coronavirus disease 2019 (COVID-19) pandemic since March 11, 2020. More than a year later, the COVID-19 vaccination brought hope to control this viral pandemic. Here, we review the unknowns of the COVID-19 vaccination, such as its longevity, asymptomatic spread, long-term side effects, and its efficacy on immunocompromised patients. In addition, we discuss challenges associated with the COVID-19 vaccination, such as the global access and distribution of vaccine doses, adherence to hygiene guidelines after vaccination, the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, and vaccine resistance. Despite all these challenges and the fact that the end of the COVID-19 pandemic is still unclear, vaccines have brought great hope for the world, with several reports indicating a significant decline in the risk of COVID19-related infection and hospitalizations.

Indexed as

VaccinationCOVID-19COVID-19 VaccinesGlobal HealthHumansImmunocompromised HostMutationSARS-CoV-2Vaccination HesitancyVaccine EfficacyCOVID-19 VaccinesCOVID-19COVID-19 vaccinationglobal assessmentglobal challengesherd immunitySARS-CoV-2

Identifiers

PMID34845731
PMCPMC9015467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.