Evidence map›Paper›PMID 34845678›Full record

ReviewDrug delivery and translational research2022

Recent advances in nanocarriers for nutrient delivery.

Srividya Gorantla, Geetika Wadhwa, Shailja Jain, Shridula Sankar, Kshitij Nuwal, Arisha Mahmood, Sunil Kumar Dubey, Rajeev Taliyan, Prashant Kesharwani, Gautam Singhvi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Advanced Oral Delivery Systems for Nutraceuticals.Advanced healthcare materials · 2025
    Review
  8. Vitamin DMolecular nutrition & food research · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. The Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Review
  17. Review
  18. CoMicromachines · 2024
    Article
  19. Review
  20. Could nanotechnology improve exercise performance? Evidence from animal studies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Srividya Gorantla *Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Geetika Wadhwa *Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Shailja JainDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Shridula SankarDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Kshitij NuwalDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Arisha MahmoodDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Sunil Kumar DubeyMedical Research, Emami Ltd, R&D Healthcare Division13, BT Road, Belgharia, Kolkata, 700056, India.
Rajeev TaliyanDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031.
Prashant KesharwaniDepartment of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. prashantdops@gmail.com.ORCID 0000-0002-0890-769X
Gautam SinghviDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani, India, 333031. gautam.singhvi@pilani.bits-pilani.ac.in.
Birla Institute of Technology and Science, Pilani · INEmami (India) · INJamia Hamdard · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the past few years, there has been a surge in the use of nutraceuticals. The global nutraceuticals market in 2020 was USD 417.66 billion, and the market value is expected to increase by 8.9% compound annual growth rate from 2020 to 2028. This is because nutraceuticals are used to treat and prevent various diseases such as cancer, skin disorders, gastrointestinal, ophthalmic, diabetes, obesity, and central nervous system-related diseases. Nutritious food provides the required amount of nutrition to the human body through diet, whereas most of the bioactive agents present in the nutrients are highly lipophilic, with low aqueous solubility leading to poor dissolution and oral bioavailability. Also, the nutraceuticals like curcumin, carotenoids, anthocyanins, omega-3 fatty acids, vitamins C, vitamin B12, and quercetin have limitations such as poor solubility, chemical instability, bitter taste, and an unpleasant odor. Additionally, the presence of gastrointestinal (GIT) membrane barriers, varied pH, and reaction with GIT enzymes cause the degradation of some of the nutraceuticals. Nanotechnology-based nutrient delivery systems can be used to improve oral bioavailability by increasing nutraceutical stability in foods and GIT, increasing nutraceutical solubility in intestinal fluids, and decreasing first-pass metabolism in the gut and liver. This article has compiled the properties and applications of various nanocarriers such as polymeric nanoparticles, micelles, liposomes, niosomes, solid lipid nanocarriers, nanostructured lipid carrier, microemulsion, nanoemulsion, dendrimers in organic nanoparticles, and nanocomposites for effective delivery of bioactive molecules.

Indexed as

AnthocyaninsNanoparticlesBiological AvailabilityDrug Delivery SystemsHumansLipidsLiposomesNutrientsAnthocyaninsLipidsLiposomesNutrientsBioactiveCancerCurcuminDiseasesDrug deliveryNanocarriersNanoformulationsNanotechnologyNutraceuticalsNutrient deliverySolubilityToxicity

Identifiers

PMID34845678
OpenAlexW3217263673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.