Evidence map›Paper›PMID 34845659›Full record

ArticleMolecular imaging and biology2023

PEGylated and Non-PEGylated TCP-1 Probes for Imaging of Colorectal Cancer.

Zhonglin Liu, Brian D Gray, Christy Barber, Li Wan, Lars R Furenlid, Rongguang Liang, Zheng Li, James M Woolfenden, Koon Y Pak, Diego R Martin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhonglin LiuDepartment of Medical Imaging at College of Medicine, University of Arizona, Tucson, AZ , USA. zliu@email.arizona.edu.ORCID 0000-0001-8259-9042
Brian D GrayMolecular Targeting Technologies, Inc., West Chester, PA, USA. briangray@mtarget.com.
Christy BarberDepartment of Medical Imaging at College of Medicine, University of Arizona, Tucson, AZ , USA.
Li WanDepartment of Medical Imaging at College of Medicine, University of Arizona, Tucson, AZ , USA.
Lars R FurenlidDepartment of Medical Imaging at College of Medicine, University of Arizona, Tucson, AZ , USA.
Rongguang LiangJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, AZ, USA.
Zheng LiHouston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
James M WoolfendenDepartment of Medical Imaging at College of Medicine, University of Arizona, Tucson, AZ , USA.
Koon Y PakMolecular Targeting Technologies, Inc., West Chester, PA, USA.
Diego R MartinDepartment of Medical Imaging at College of Medicine, University of Arizona, Tucson, AZ , USA.
University of Arizona · USHouston Methodist · USMolecular Targeting Technologies (United States) · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
CENTER FOR GAMMA RAY IMAGINGP41EB002035 · NIBIB · UNIVERSITY OF ARIZONA · PI BARRETT, HARRISON H, FURENLID, LARS R · 2003 to 2018
$17.7M
Novel molecular probes for imaging colorectal cancerR21CA216657 · NCI · UNIVERSITY OF ARIZONA · PI GRAY, BRIAN DAVID, LIU, ZHONGLIN · 2018 to 2019
$349k
NCI NIH HHS P30 CA023074NCI NIH HHS P30-CA023074NCI NIH HHS R21 CA216657NIBIB NIH HHS P41 EB002035NIBIB NIH HHS P41-EB002035
6 · The paper itself

Abstract

purposePrevious studies indicate that PROCEDURES: Cell uptake of cyanine 7 (Cy7)-labeled TCP-1 probes (Cy7-PEG

resultsFluorescence images showed that TCP-1 probes were distributed in the cytoplasm and nucleus of CRC cells. When CT26 cells were treated with unlabeled TCP-1 peptide prior to the cell incubation with Cy7-PEG

conclusionsTCP-1-based probes undergo endocytosis and localize in the cytoplasm and nucleus of human and mouse CRC cells. Tumor detectability of fluorescent TCP-1 peptide with a PEG

Indexed as

Colorectal NeoplasmsPeptidesAnimalsCell Line, TumorHumansMiceOrganotechnetium CompoundsTissue DistributionTomography, Emission-Computed, Single-PhotonOrganotechnetium CompoundsPeptides99mTcColorectal cancerFluorescenceMolecular imagingTCP-1 peptide

Identifiers

PMID34845659
PMCPMC9148376
OpenAlexW3216381400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.