Evidence map›Paper›PMID 34845629›Full record

ArticleSleep & breathing = Schlaf & Atmung2022

Gestational chronic intermittent hypoxia induces hypertension, proteinuria, and fetal growth restriction in mice.

Cuilian Weng, Long Huang, Hangwei Feng, Quanying He, Xingsheng Lin, Tingting Jiang, Jian Lin, Xincai Wang, Qinghua Liu

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Gestational Intermittent Hypoxia Impairs ATJournal of biotechnology and biomedicine · 2024
    Article
  8. The impact of hypoxia on extracellular vesicle secretome profile of cancer.Medical oncology (Northwood, London, England) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cuilian Weng *Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Long Huang *Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Hangwei Feng *Department of Critical Care Medicine, Fujian Provincial Hospital South Branch, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Quanying HeDepartment of Respirology, Peking University People's Hospital, Beijing, China.
Xingsheng LinDepartment of Critical Care Medicine, Fujian Provincial Hospital South Branch, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Tingting JiangDepartment of Pharmacy, Fujian Provincial Hospital South Branch, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Jian LinDepartment of Critical Care Medicine, Fujian Provincial Hospital South Branch, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Xincai WangDepartment of Critical Care Medicine, Fujian Provincial Hospital South Branch, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Qinghua LiuDepartment of Otorhinolaryngology, Fujian Provincial Hospital, The Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, 134 Dongjie Street, Fuzhou, Fujian Province, China. 15280096007@163.com.ORCID 0000-0002-7164-9734
Fujian Medical University · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePregnant women are predisposed to obstructive sleep apnea (OSA). Based on the fact that OSA is an independent risk factor for hypertension among the general population, we hypothesized that chronic intermittent hypoxia (CIH), as a feature of OSA, may lead to preeclampsia.

methodsPregnant and non-pregnant C57BL/6 J mice were exposed to two conditions of chronic intermittent hypoxia: CIH1 (21-5% O

resultsIn non-pregnant mice, compared with their respective baseline values, systolic blood pressure (SBP) started to rise from day 14 in the CIH1 group, and SBP rose until day 19 in the CIH2 group. Compared with the pregnant mice exposed to room air, pregnant mice exposed to CIH1 maintained elevated SBP from day 14, accompanied by proteinuria, fetal and placental growth restriction, and a reduction in the number of fetuses. An imbalance between proangiogenic and antiangiogenic factors and impairment of vascular remodeling existed in the placenta of pregnant mice exposed to CIH1. Maternal serum levels of the soluble form of vascular endothelial growth factor receptor-1 were also significantly increased. Pregnant mice exposed to CIH2 seemed to have milder changes than pregnant mice exposed to CIH1.

conclusionOur results demonstrated that gestational CIH may induce gestational hypertension, proteinuria, fetal and placental growth restriction as well as impairments in placental angiogenesis and vascular remodeling.

Indexed as

HypertensionSleep Apnea, ObstructiveAnimalsDisease Models, AnimalFemaleFetal Growth RetardationHumansHypoxiaMiceMice, Inbred C57BLPlacentaPregnancyProteinuriaVascular Endothelial Growth Factor AVascular RemodelingVascular Endothelial Growth Factor AIntermittent hypoxiaObstructivePreeclampsiaSleep apnea

Identifiers

PMID34845629
OpenAlexW3215974831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.