Evidence map›Paper›PMID 34845449›Full record

ArticlebioRxiv : the preprint server for biology2021

LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry

Jaewon Song, Ryan D Chow, Mario Pena-Hernandez, Li Zhang, Skylar A Loeb, Eui-Young So, Olin D Liang, Craig B Wilen, Sanghyun Lee

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jaewon SongDepartment of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA.
Ryan D ChowDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.
Mario Pena-HernandezDepartment of Laboratory Medicine, Yale University, New Haven, Connecticut, USA.
Li ZhangDepartment of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA.
Skylar A LoebDepartment of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA.
Eui-Young SoDivision of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Olin D LiangDivision of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Craig B WilenDepartment of Laboratory Medicine, Yale University, New Haven, Connecticut, USA.
Sanghyun LeeDepartment of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA.
Brown University · USYale University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Stem Cells and AgingP20GM119943 · NIGMS · RHODE ISLAND HOSPITAL · PI WEBB, ASHLEY E · 2017 to 2021
$10.6M
The role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9M
Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940k
A Secreted Viral Protein Determines Norovirus Persistence By Immune EvasionR00AI141683 · NIAID · BROWN UNIVERSITY · PI LEE, SANGHYUN · 2020 to 2021
$493k
Mechanosensation in tumorigenesis and metastasisF30CA250249 · NCI · YALE UNIVERSITY · PI CHOW, RYAN D · 2020 to 2022
$113k
NCI NIH HHS F30 CA250249NIAID NIH HHS K08 AI128043NIAID NIH HHS R00 AI141683NIAID NIH HHS R01 AI148467NIGMS NIH HHS P20 GM119943NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

SARS-CoV-2 infection is mediated by the entry receptor ACE2. Although attachment factors and co-receptors facilitating entry are extensively studied, cellular entry factors inhibiting viral entry are largely unknown. Using a

Indexed as

COVID-19inhibitory receptorLRRC15SARS-CoV-2viral entry

Identifiers

PMID34845449
PMCPMC8629192
OpenAlexW3215705467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.