Evidence map›Paper›PMID 34845413›Full record

ArticleComputational and mathematical methods in medicine2021

VEGF Family Gene Expression as Prognostic Biomarkers for Alzheimer's Disease and Primary Liver Cancer.

Kai Xu, Chuan-Ling Wu, Zhi-Xin Wang, Hai-Jiu Wang, Feng-Jiao Yin, Wen-Deng Li, Chu-Chu Liu, Hai-Ning Fan

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kai XuDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, China.
Chuan-Ling WuJianhu College, Zhejiang Industry Polytechnic College, China.
Zhi-Xin WangDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, China.ORCID https://orcid.org/0000-0001-7222-7069
Hai-Jiu WangDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, China.ORCID https://orcid.org/0000-0003-1353-483X
Feng-Jiao YinDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, China.
Wen-Deng LiDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, China.
Chu-Chu LiuDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, China.
Hai-Ning FanDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, China.
Qinghai University Affiliated Hospital · CNZhejiang Industry Polytechnic College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo analyze the expression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) and cognitive impairment, explore the relationship between the expression of VEGF family genes and prognosis of patients with HCC, and evaluate the predictive ability of VEGF in cognitive impairment using computerized methods.

methodsVEGF expression in liver cancer tissues and normal tissues was analyzed using bioinformatics methods. The Kaplan-Meier survival analysis method was also used to analyze the relationship between VEGF expression and the prognosis of patients with HCC. Furthermore, immune infiltration assessment and gene set enrichment analysis were performed. Meanwhile, the differential expression of VEGF family genes between patients with Alzheimer's disease (AD) and healthy controls was also checked.

resultsBased on The Cancer Genome Atlas (TCGA) database, the VEGF family genes (

conclusionsVEGF is highly expressed in patients with HCC and lowly expressed in patients with AD. VEGF has opposite opposing roles in the treatment of tumors and cognitive impairment.

Indexed as

Alzheimer DiseaseBiomarkers, TumorCarcinoma, HepatocellularCase-Control StudiesComputational BiologyDatabases, GeneticGene ExpressionGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic MarkersHumansKaplan-Meier EstimateLiver NeoplasmsPrognosisRisk FactorsVascular Endothelial Growth Factor ABiomarkers, TumorGenetic MarkersVascular Endothelial Growth Factor AVascular Endothelial Growth Factor BVascular Endothelial Growth Factor CVascular Endothelial Growth Factor DVascular Endothelial Growth FactorsVEGFA protein, humanVEGFB protein, humanVEGFC protein, humanVEGFD protein, human

Identifiers

PMID34845413
PMCPMC8627334
OpenAlexW3214844284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.