Evidence map›Paper›PMID 34845407›Full record

ArticleMediators of inflammation2021

High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice.

Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang and 1 more

Abstract read
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lu LuoDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7670-0773
Meixi LiuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-8790-682X
Hongyu XieDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-6386-8083
Yunhui FanDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7350-9084
Jingjun ZhangDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-8394-1292
Li LiuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-1239-3705
Yun LiDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-9854-1360
Qiqi ZhangDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-8467-6048
Junfa WuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-5742-9244
Congyu JiangDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2179-8213
Yi WuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4955-3533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although skeletal muscle is the main effector organ largely accounting for disability after stroke, considerably less attention is paid to the secondary abnormalities of stroke-related skeletal muscle loss. It is necessary to explore the mechanism of muscle atrophy after stroke and further develop effective rehabilitation strategy. Here, we evaluated the effects of high-intensity interval (HIIT) versus moderate-intensity aerobic training (MOD) on physical function, muscle mass, and stroke-related gene expression profile of skeletal muscle. After the model of middle cerebral artery occlusion (MCAO) was successfully made, the blood lactate threshold corresponding speed (

Indexed as

High-Intensity Interval TrainingPhysical Conditioning, AnimalAnimalsBrain IschemiaCytokinesGaitInflammationLungMacrophagesMaleMiceMice, Inbred C57BLMuscle, SkeletalSignal TransductionToll-Like Receptor 8CytokinesTLR8 protein, mouseToll-Like Receptor 8

Identifiers

PMID34845407
PMCPMC8627337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.