Evidence map›Paper›PMID 34845312›Full record

ArticleScientific reports2021

Additive and interaction effects of working memory and motor sequence training on brain functional connectivity.

Priska Zuber, Laura Gaetano, Alessandra Griffa, Manuel Huerbin, Ludovico Pedullà, Laura Bonzano, Anna Altermatt, Charidimos Tsagkas, Katrin Parmar, Patric Hagmann and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Priska ZuberDivision of Cognitive Neuroscience, Faculty of Psychology, University of Basel, Basel, Switzerland.
Laura GaetanoF. Hoffmann-La Roche Ltd., Basel, Switzerland.
Alessandra GriffaDepartment of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Manuel HuerbinMedical Image Analysis Center (MIAC AG), Basel, Switzerland.
Ludovico PedullàDepartment of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, Italy.
Laura BonzanoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Anna AltermattMedical Image Analysis Center (MIAC AG), Basel, Switzerland.
Charidimos TsagkasNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Katrin ParmarNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Patric HagmannCenter of Neuroprosthetics, Institute of Bioengineering, École Polytechnique Fédérale De Lausanne (EPFL), Geneva, Switzerland.
Jens WuerfelMedical Image Analysis Center (MIAC AG), Basel, Switzerland.
Ludwig KapposNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Till SprengerDepartment of Neurology, DKD Helios Klinik, Wiesbaden, Germany.
Olaf SpornsDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Stefano MagonNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland. stefano.magon@roche.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although shared behavioral and neural mechanisms between working memory (WM) and motor sequence learning (MSL) have been suggested, the additive and interactive effects of training have not been studied. This study aimed at investigating changes in brain functional connectivity (FC) induced by sequential (WM + MSL and MSL + WM) and combined (WM × MSL) training programs. 54 healthy subjects (27 women; mean age: 30.2 ± 8.6 years) allocated to three training groups underwent twenty-four 40-min training sessions over 6 weeks and four cognitive assessments including functional MRI. A double-baseline approach was applied to account for practice effects. Test performances were compared using linear mixed-effects models and t-tests. Resting state fMRI data were analysed using FSL. Processing speed, verbal WM and manual dexterity increased following training in all groups. MSL + WM training led to additive effects in processing speed and verbal WM. Increased FC was found after training in a network including the right angular gyrus, left superior temporal sulcus, right superior parietal gyrus, bilateral middle temporal gyri and left precentral gyrus. No difference in FC was found between double baselines. Results indicate distinct patterns of resting state FC modulation related to sequential and combined WM and MSL training suggesting a relevance of the order of training performance. These observations could provide new insight for the planning of effective training/rehabilitation.

Indexed as

Memory, Short-TermMotor SkillsAdultBrainBrain MappingCognitionFemaleHealthy VolunteersHumansImage Processing, Computer-AssistedLearningLinear ModelsMagnetic Resonance ImagingMaleMemoryMiddle Aged

Identifiers

PMID34845312
PMCPMC8630199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.