Evidence map›Paper›PMID 34845263›Full record

ArticleScientific reports2021

Evolutionary dynamics of HIV-1 subtype C in Brazil.

Bernardino Souto, Vera Triunfante, Ana Santos-Pereira, Joana Martins, Pedro M M Araújo, Nuno S Osório

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  8. Per-pathogen virulence of HIV-1 subtypes A, C and D.Proceedings. Biological sciences · 2023
    Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bernardino Souto *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Vera Triunfante *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Ana Santos-Pereira *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Joana MartinsLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Pedro M M AraújoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Nuno S OsórioLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. nosorio@med.uminho.pt.
University of Minho · PTUniversidade Federal de São Carlos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extensive genetic diversity of HIV-1 is a major challenge for the prevention and treatment of HIV-1 infections. Subtype C accounts for most of the HIV-1 infections in the world but has been mainly localized in Southern Africa, Ethiopia and India. For elusive reasons, South Brazil harbors the largest HIV-1 subtype C epidemic in the American continent that is elsewhere dominated by subtype B. To investigate this topic, we collected clinical data and viral sequences from 2611 treatment-naïve patients diagnosed with HIV-1 in Brazil. Molecular epidemiology analysis supported 35 well-delimited transmission clusters of subtype C highlighting transmission within South Brazil but also from the South to all other Brazilian regions and internationally. Individuals infected with subtype C had lower probability to be deficient in CD4

Indexed as

Evolution, MolecularGenetic VariationMolecular EpidemiologyAdolescentAdultAgedBrazilCD4-Positive T-LymphocytesChildChild, PreschoolFemaleGenotypeGeographyHIV-1HIV InfectionsHIV Seropositivity

Identifiers

PMID34845263
PMCPMC8629974
OpenAlexW3216778861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.