Evidence map›Paper›PMID 34845260›Full record

ArticleScientific reports2021

Insights into the palaeobiology of an early Homo infant: multidisciplinary investigation of the GAR IVE hemi-mandible, Melka Kunture, Ethiopia.

Adeline Le Cabec, Thomas Colard, Damien Charabidze, Catherine Chaussain, Gabriele Di Carlo, Sabine Gaudzinski-Windheuser, Jean-Jacques Hublin, Rita T Melis, Laura Pioli, Fernando Ramirez-Rozzi and 1 more

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In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Adeline Le CabecDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany. adeline_lecabec@eva.mpg.de.
Thomas ColardDepartment of Orthodontics, University of Lille, Lille University Hospital, 59000, Lille, France.
Damien CharabidzeUMR 8025, Centre d'Histoire Judiciaire, University of Lille, 59000, Lille, France.
Catherine ChaussainUR 2496 Orofacial Pathologies, Imaging and Biotherapies. Dental School Université de Paris, AP-HP- Hôpital Bretonneau - Service Odontologie CRMR Métabolisme du Phosphore et du Calcium (OSCAR, ERN Bond), Paris, France.
Gabriele Di CarloDepartment of Oral and Maxillofacial Sciences, Unit of Pediatric Dentistry, Sapienza University of Rome, Rome, Italy.
Sabine Gaudzinski-WindheuserMONREPOS Archaeological Research Centre and Museum for Human Behavioural Evolution, Römisch-Germanisches Zentralmuseum, Leibniz-Forschungsinstitut Für Archäologie and Institute of Ancient Studies, Johannes Gutenberg-University Mainz, Schloss Monrepos, 56567, Neuwied, Germany.
Jean-Jacques HublinDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany.
Rita T MelisItalian Archaeological Mission at Melka Kunture and Balchit, Rome, Italy.
Laura PioliDipartimento Di Scienze Chimiche E Geologiche, Università Degli Studi Di Cagliari, Cittadella Universitaria, 09042, Monserrato (CA), Italy.
Fernando Ramirez-RozziUR 2496 Orofacial Pathologies, Imaging and Biotherapies. Dental School Université de Paris, AP-HP- Hôpital Bretonneau - Service Odontologie CRMR Métabolisme du Phosphore et du Calcium (OSCAR, ERN Bond), Paris, France.
Margherita MussiItalian Archaeological Mission at Melka Kunture and Balchit, Rome, Italy. margherita.mussi@fondazione.uniroma1.it.
Deutsches Archäologisches Institut, Abteilung Rom · ITMax Planck Institute for Evolutionary Anthropology · DEUniversité de Lille · FRUniversité Paris Cité · FRJohannes Gutenberg University Mainz · DESapienza University of Rome · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood is an ontogenetic stage unique to the modern human life history pattern. It enables the still dependent infants to achieve an extended rapid brain growth, slow somatic maturation, while benefitting from provisioning, transitional feeding, and protection from other group members. This tipping point in the evolution of human ontogeny likely emerged from early Homo. The GAR IVE hemi-mandible (1.8 Ma, Melka Kunture, Ethiopia) represents one of the rarely preserved early Homo infants (~ 3 years at death), recovered in a richly documented Oldowan archaeological context. Yet, based on the sole external inspection of its teeth, GAR IVE was diagnosed with a rare genetic disease-amelogenesis imperfecta (AI)-altering enamel. Since it may have impacted the child's survival, this diagnosis deserves deeper examination. Here, we reassess and refute this diagnosis and all associated interpretations, using an unprecedented multidisciplinary approach combining an in-depth analysis of GAR IVE (synchrotron imaging) and associated fauna. Some of the traits previously considered as diagnostic of AI can be better explained by normal growth or taphonomy, which calls for caution when diagnosing pathologies on fossils. We compare GAR IVE's dental development to other fossil hominins, and discuss the implications for the emergence of childhood in early Homo.

Indexed as

Amelogenesis ImperfectaAnimalsArchaeologyBiological EvolutionDental EnamelEthiopiaFemaleFossilsGeographyHeadHominidaeHumansInterdisciplinary ResearchMandiblePaleontologySynchrotrons

Identifiers

PMID34845260
PMCPMC8630034
OpenAlexW3216769000

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.