Evidence map›Paper›PMID 34845247›Full record

ArticleNPJ schizophrenia2021

Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis.

Shinsuke Koike, Mao Fujioka, Yoshihiro Satomura, Daisuke Koshiyama, Mariko Tada, Eisuke Sakakibara, Naohiro Okada, Yosuke Takano, Norichika Iwashiro, Tatsunobu Natsubori and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ schizophrenia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shinsuke KoikeUniversity of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), Meguro-ku, Tokyo, 153-8902, Japan. skoike-tky@umin.ac.jp.ORCID http://orcid.org/0000-0002-3375-236X
Mao FujiokaDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yoshihiro SatomuraDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Daisuke KoshiyamaDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Mariko TadaDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Eisuke SakakibaraDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Naohiro OkadaThe International Research Center for Neurointelligence (WPI-IRCN), Institutes for Advanced Study (UTIAS), University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan.
Yosuke TakanoDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Norichika IwashiroDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Tatsunobu NatsuboriDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yinghan ZhuCenter for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Meguro-ku, Tokyo, 153-8902, Japan.
Osamu AbeDepartment of Radiology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0002-1180-2629
Kenji KiriharaDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Hidenori YamasueDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu City, 431-3192, Japan.
Kiyoto KasaiUniversity of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), Meguro-ku, Tokyo, 153-8902, Japan.

Funding

Japan Agency for Medical Research and Development (AMED) JP21dm0207069Japan Agency for Medical Research and Development (AMED) JP21dm0307001Japan Agency for Medical Research and Development (AMED) JP21dm0307004MEXT | Japan Science and Technology Agency (JST) JPMJMS2021MEXT | Japan Society for the Promotion of Science (JSPS) 19H03579MEXT | Japan Society for the Promotion of Science (JSPS) 20KK0193MEXT | Japan Society for the Promotion of Science (JSPS) 21H02851
6 · The paper itself

Abstract

Many studies have tested the relationship between demographic, clinical, and psychobiological measurements and clinical outcomes in ultra-high risk for psychosis (UHR) and first-episode psychosis (FEP). However, no study has investigated the relationship between multi-modal measurements and long-term outcomes for >2 years. Thirty-eight individuals with UHR and 29 patients with FEP were measured using one or more modalities (cognitive battery, electrophysiological response, structural magnetic resonance imaging, and functional near-infrared spectroscopy). We explored the characteristics associated with 13- and 28-month clinical outcomes. In UHR, the cortical surface area in the left orbital part of the inferior frontal gyrus was negatively associated with 13-month disorganized symptoms. In FEP, the cortical surface area in the left insula was positively associated with 28-month global social function. The left inferior frontal gyrus and insula are well-known structural brain characteristics in schizophrenia, and future studies on the pathological mechanism of structural alteration would provide a clearer understanding of the disease.

Identifiers

PMID34845247
PMCPMC8630202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.