ArticleNature communications2021
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.
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In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- The endothelial scavenger receptorbioRxiv : the preprint server for biology · 2026Article
- A human pathophysiological 3D-bone marrow model reveals immune and stromal cell heterogeneity.Communications biology · 2026Article
- Polyclonal regeneration of mouse bone marrow endothelial cells after irradiative conditioning.Cell reports · 2024Article
- Fenestrated Endothelial Cells across Organs: Insights into Kidney Function and Disease.International journal of molecular sciences · 2024Review
- Complementary and Inducible creERStem cell reviews and reports · 2024Article
- Whole-Genome Identification and Characterization of the DKK Gene Family and Its Transcription Profiles: An Analysis of the Chinese Soft-Shell Turtle (Animals : an open access journal from MDPI · 2024Article
- Article
- Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia.Blood advances · 2023Article
- Article
- CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple.Current osteoporosis reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 6 institutions in 3 countries.
Joschka Heil *Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Victor Olsavszky *Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany. victor.olsavszky@umm.de.ORCID 0000-0001-6083-5534
Katrin BuschDivision of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kay KlapprothDivision of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carolina de la TorreCore Facility Platform Mannheim (CFPM), NGS Core Facility, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0001-8918-2266
Carsten StichtCore Facility Platform Mannheim (CFPM), NGS Core Facility, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Kajetan SandorskiDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Johannes HoffmannDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.ORCID 0000-0002-2774-7847
Hiltrud SchönhaberDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Johanna ZierowDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Manuel WinklerDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.ORCID 0000-0003-2415-9350
Christian David SchmidDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.ORCID 0000-0002-4401-3394
Theresa StaniczekDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.ORCID 0000-0002-3137-3833
Deborah E DanielsSchool of Biochemistry, University of Bristol, Bristol, UK.ORCID 0000-0003-3023-824X
Jan FrayneSchool of Biochemistry, University of Bristol, Bristol, UK.
Georgia MetzgerothDepartment for Hematology and Oncology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Daniel NowakDepartment for Hematology and Oncology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0001-7130-7921
Sven SchneiderInstitute for Clinical Chemistry, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Michael NeumaierInstitute for Clinical Chemistry, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vanessa WeyerDepartment of Neuroradiology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Christoph GrodenDepartment of Neuroradiology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hermann-Josef GröneInstitute of Pharmacology, Philipps-University, Marburg, Germany.
Karsten RichterDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carolin MoglerInstitute of Pathology, Technical University Munich, Munich, Germany.ORCID 0000-0003-3400-7254
Makoto Mark TaketoDivision of Experimental Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kai SchledzewskiDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.ORCID 0000-0002-0107-1674
Cyrill GéraudDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Sergij GoerdtDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Philipp-Sebastian KochDepartment of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany. philipp.koch@umm.de.ORCID 0000-0001-5236-0516
Heidelberg University · DEGerman Cancer Research Center · DEUniversity of Bristol · GBKyoto University · JPPhilipps University of Marburg · DETechnical University of Munich · DE
Funding
Medical Research Council MR/S021140/1
Abstract
Within the bone marrow microenvironment, endothelial cells (EC) exert important functions. Arterial EC support hematopoiesis while H-type capillaries induce bone formation. Here, we show that BM sinusoidal EC (BM-SEC) actively control erythropoiesis. Mice with stabilized β-catenin in BM-SEC (Ctnnb1
Indexed as
AnemiaAnimalsbeta CateninBone MarrowCapillariesCell Adhesion Molecules, NeuronalCell DifferentiationEndothelial CellsEndothelium, VascularErythroblastsErythropoiesisFemaleFibroblast Growth Factor-23Gene Expression RegulationHematopoietic Stem CellsHematopoietic Stem Cell Transplantationbeta CateninCell Adhesion Molecules, NeuronalCre recombinaseCTNNB1 protein, mouseDkk2 protein, mouseFgf23 protein, mouseFibroblast Growth Factor-23IntegrasesIntercellular Signaling Peptides and ProteinsStab2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.