Evidence map›Paper›PMID 34845224›Full record

ArticleNPJ Parkinson's disease2021

A real-world study of wearable sensors in Parkinson's disease.

Jamie L Adams, Karthik Dinesh, Christopher W Snyder, Mulin Xiong, Christopher G Tarolli, Saloni Sharma, E Ray Dorsey, Gaurav Sharma

Open access · goldAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
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  10. Digital Technologies for Symptom Monitoring in Parkinson Disease.Current neurology and neuroscience reports · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jamie L AdamsDepartment of Neurology, University of Rochester Medical Center, Rochester, NY, USA. jamie_adams@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-1170-6688
Karthik DineshDepartment of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-6042-6079
Christopher W SnyderRochester General Hospital, Microbiology, Rochester, NY, USA.
Mulin XiongMichigan State University College of Human Medicine, East Lansing, MI, USA.
Christopher G TarolliDepartment of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
Saloni SharmaCenter for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA.
E Ray DorseyDepartment of Neurology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-5140-1248
Gaurav SharmaDepartment of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-9735-9519
University of Rochester Medical Center · USUniversity of Rochester · USMichigan State University · USRochester General Hospital · US

Funding

The Clinical Core will support in-person and virtual research visits for three of the four Research Projects at the University of Rochester Udall CenterP50NS108676 · NINDS · UNIVERSITY OF ROCHESTER · PI DORSEY, EARL RAY · 2018 to 2022
$9.2M
NINDS NIH HHS P50 NS108676
6 · The paper itself

Abstract

Most wearable sensor studies in Parkinson's disease have been conducted in the clinic and thus may not be a true representation of everyday symptoms and symptom variation. Our goal was to measure activity, gait, and tremor using wearable sensors inside and outside the clinic. In this observational study, we assessed motor features using wearable sensors developed by MC10, Inc. Participants wore five sensors, one on each limb and on the trunk, during an in-person clinic visit and for two days thereafter. Using the accelerometer data from the sensors, activity states (lying, sitting, standing, walking) were determined and steps per day were also computed by aggregating over 2 s walking intervals. For non-walking periods, tremor durations were identified that had a characteristic frequency between 3 and 10 Hz. We analyzed data from 17 individuals with Parkinson's disease and 17 age-matched controls over an average 45.4 h of sensor wear. Individuals with Parkinson's walked significantly less (median [inter-quartile range]: 4980 [2835-7163] steps/day) than controls (7367 [5106-8928] steps/day; P = 0.04). Tremor was present for 1.6 [0.4-5.9] hours (median [range]) per day in most-affected hands (MDS-UPDRS 3.17a or 3.17b = 1-4) of individuals with Parkinson's, which was significantly higher than the 0.5 [0.3-2.3] hours per day in less-affected hands (MDS-UPDRS 3.17a or 3.17b = 0). These results, which require replication in larger cohorts, advance our understanding of the manifestations of Parkinson's in real-world settings.

Identifiers

PMID34845224
PMCPMC8629990
OpenAlexW3217646093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.