Evidence map›Paper›PMID 34845210›Full record

ReviewNPJ vaccines2021

Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission.

Yacob Keleta, Julian Ramelow, Liwang Cui, Jun Li

Open access · goldAbstract readReview
In one paragraph

Review in NPJ vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Molecular mechanisms involved inFrontiers in microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yacob KeletaDepartment of Biological Sciences, Florida International University, Miami, FL, 33199, USA.
Julian RamelowHerbert Wertheim College of Medicine, Florida International University, Miami, FL, 33199, USA.
Liwang CuiCollege of Public Health, University of South Florida, Tampa, FL, 33612, USA.
Jun LiDepartment of Biological Sciences, Florida International University, Miami, FL, 33199, USA. lij@fiu.edu.ORCID http://orcid.org/0000-0002-2121-3393
Florida International University · USUniversity of South Florida · US

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
Fungal metabolites block malaria transmissionR01AI125657 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LI, JUN · 2017 to 2021
$2.5M
NIAID NIH HHS R01 AI125657NIAID NIH HHS U19 AI089672
6 · The paper itself

Abstract

Despite considerable effort, malaria remains a major public health burden. Malaria is caused by five Plasmodium species and is transmitted to humans via the female Anopheles mosquito. The development of malaria vaccines against the liver and blood stages has been challenging. Therefore, malaria elimination strategies advocate integrated measures, including transmission-blocking approaches. Designing an effective transmission-blocking strategy relies on a sophisticated understanding of the molecular mechanisms governing the interactions between the mosquito midgut molecules and the malaria parasite. Here we review recent advances in the biology of malaria transmission, focusing on molecular interactions between Plasmodium and Anopheles mosquito midgut proteins. We provide an overview of parasite and mosquito proteins that are either targets for drugs currently in clinical trials or candidates of promising transmission-blocking vaccines.

Identifiers

PMID34845210
PMCPMC8630063
OpenAlexW3215554334

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.