Evidence map›Paper›PMID 34845206›Full record

ArticleNature communications2021

Multi-species host range of staphylococcal phages isolated from wastewater.

Pauline C Göller, Tabea Elsener, Dominic Lorgé, Natasa Radulovic, Viona Bernardi, Annika Naumann, Nesrine Amri, Ekaterina Khatchatourova, Felipe Hernandes Coutinho, Martin J Loessner and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
  6. Article
  7. mBio · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Host range of 30 novelmicroPublication biology · 2026
    Article
  12. Isolation, characterization, andFrontiers in microbiology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Draft genome sequences ofMicrobiology resource announcements · 2025
    Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pauline C GöllerInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Tabea ElsenerInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Dominic LorgéInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Natasa RadulovicInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Viona BernardiInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Annika NaumannInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Nesrine AmriInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Ekaterina KhatchatourovaInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Felipe Hernandes CoutinhoDepartamento de Producción Vegetal y Microbiología, Universidad Miguel Hernández, San Juan de Alicante, Spain.
Martin J LoessnerInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8162-2631
Elena Gómez-SanzInstitute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland. elena.gomez@hest.ethz.ch.ORCID http://orcid.org/0000-0001-7666-3642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The host range of bacteriophages defines their impact on bacterial communities and genome diversity. Here, we characterize 94 novel staphylococcal phages from wastewater and establish their host range on a diversified panel of 117 staphylococci from 29 species. Using this high-resolution phage-bacteria interaction matrix, we unveil a multi-species host range as a dominant trait of the isolated staphylococcal phages. Phage genome sequencing shows this pattern to prevail irrespective of taxonomy. Network analysis between phage-infected bacteria reveals that hosts from multiple species, ecosystems, and drug-resistance phenotypes share numerous phages. Lastly, we show that phages throughout this network can package foreign genetic material enclosing an antibiotic resistance marker at various frequencies. Our findings indicate a weak host specialism of the tested phages, and therefore their potential to promote horizontal gene transfer in this environment.

Indexed as

Genome, ViralHost SpecificityWastewaterAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialEcosystemGene Transfer, HorizontalMicrobial ConsortiaMicrobial Sensitivity TestsPhylogenyStaphylococcusStaphylococcus PhagesWater MicrobiologyAnti-Bacterial AgentsWastewater

Identifiers

PMID34845206
PMCPMC8629997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.