Evidence map›Paper›PMID 34845016›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Recognition of the antigen-presenting molecule MR1 by a Vδ3

Michael T Rice, Anouk von Borstel, Priyanka Chevour, Wael Awad, Lauren J Howson, Dene R Littler, Nicholas A Gherardin, Jérôme Le Nours, Edward M Giles, Richard Berry and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 65 citations in OpenAlex.

  1. Enrichment of CD4iScience · 2026
    Article
  2. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Review
  4. Article
  5. Harnessing Vδ1Frontiers in immunology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
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  11. Review
  12. Review
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Michael T RiceInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-2693-0252
Anouk von BorstelInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-3605-7936
Priyanka ChevourInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-7113-9435
Wael AwadInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-7597-2133
Lauren J HowsonInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0003-3522-4533
Dene R LittlerInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0001-5904-1905
Nicholas A GherardinDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.ORCID 0000-0003-4690-2571
Jérôme Le NoursInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-2221-7636
Edward M GilesDepartment of Paediatrics, Monash University, Clayton, VIC 3168, Australia.ORCID 0000-0003-3295-1575
Richard BerryInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0001-7043-0469
Dale I GodfreyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.ORCID 0000-0002-3009-5472
Martin S DaveyInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; martin.davey@monash.edu jamie.rossjohn@monash.edu ben.gully@monash.edu.ORCID 0000-0002-3463-3127
Jamie RossjohnInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; martin.davey@monash.edu jamie.rossjohn@monash.edu ben.gully@monash.edu.ORCID 0000-0002-2020-7522
Benjamin S GullyInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; martin.davey@monash.edu jamie.rossjohn@monash.edu ben.gully@monash.edu.ORCID 0000-0002-8197-0871
Australian Research Council · AUAustralian Regenerative Medicine Institute · AUHudson Institute of Medical Research · AU

Funding

Investigating the basis of MAIT cell antigen potencyR01AI148407 · NIAID · UNIVERSITY OF MELBOURNE · PI MCCLUSKEY, JAMES · 2020 to 2024
$2.7M
NIAID NIH HHS R01 AI148407
6 · The paper itself

Abstract

Unlike conventional αβ T cells, γδ T cells typically recognize nonpeptide ligands independently of major histocompatibility complex (MHC) restriction. Accordingly, the γδ T cell receptor (TCR) can potentially recognize a wide array of ligands; however, few ligands have been described to date. While there is a growing appreciation of the molecular bases underpinning variable (V)δ1

Indexed as

AdultAntigen PresentationFemaleHistocompatibility Antigens Class IHumansIntraepithelial LymphocytesLigandsMaleMinor Histocompatibility AntigensMucosal-Associated Invariant T CellsReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaHistocompatibility Antigens Class ILigandsMinor Histocompatibility AntigensMR1 protein, humanReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaMR1structural immunologyγδTCR

Identifiers

PMID34845016
PMCPMC8694053
OpenAlexW3216161734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.