Evidence map›Paper›PMID 34844870›Full record

ArticleBrazilian journal of otorhinolaryngology

Prevalence of respiratory epithelial adenomatoid hamartomas (REAH) associated with nasal polyposis: an epidemiological study - how to diagnose.

Maria Julia Abrão Issa, Vitor Ramos Ribeiro de Oliveira, Flavio Barbosa Nunes, Luís Otávio Giovanardi Vasconcelos, Luiz Felipe Bartolomeu Souza, Giancarlo Bonotto Cherobin, Roberto Eustáquio Santos Guimarães

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Comparative outcomes of nasalisation vs functional endoscopic sinus surgery in chronic rhinosinusitis with nasal polyposis: a 10-year retrospective study.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Article
  3. Article
  4. Article
  5. Sinonasal Hamartoma and Chronic Laryngeal Edema Causing Severe Dyspnea.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maria Julia Abrão IssaUniversidade Federal de Minas Gerais (UFMG), Programa de Otorrinolaringologia, Belo Horizonte, MG, Brazil.
Vitor Ramos Ribeiro de OliveiraUniversidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Flavio Barbosa NunesUniversidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Otorrinolaringologia, Belo Horizonte, MG, Brazil.
Luís Otávio Giovanardi VasconcelosNúcleo de Otorrino BH, Belo Horizonte, MG, Brazil.
Luiz Felipe Bartolomeu SouzaUniversidade Federal de Minas Gerais (UFMG), Hospital Universitário, Belo Horizonte, MG, Brazil.
Giancarlo Bonotto CherobinUniversidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Otorrinolaringologia, Belo Horizonte, MG, Brazil.
Roberto Eustáquio Santos GuimarãesUniversidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Otorrinolaringologia, Belo Horizonte, MG, Brazil; Universidade de São Paulo, Ribeirão Preto, SP, Brazil; Academia de Medicina de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: resguimaraes@gmail.com.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo highlight the prevalence of respiratory epithelial adenomatoid hamartomas in the olfactory cleft of patients with nasal polyposis. To demonstrate characteristics indicative of hamartoma on the CT scans of paranasal sinuses during surgery and in histopathological exams.

methodsCross-sectional study carried out in Hospital das Clínicas da UFMG and Núcleo de Otorrino BH. We performed 114 nasal endoscopic surgeries for polyposis, between February 2015 and November 2019. We assessed the olfactory cleft width in all preoperative CT scans. Upon seeing an indication of hamartoma on the CT scan, we took a tissue sample from the olfactory cleft during the surgery and sent for histopathological exam. We referred the samples to a pathologist experienced in the anatomopathological diagnosis of respiratory epithelial adenomatoid hamartomas.

resultsOf the 114 patients with polyposis, 54 (47.4%) had olfactory cleft enlargement and, 100% of them had tissue with a dense and hardened polypoid aspect, with a slight cerebriform appearance in this region during the surgery. Histology confirmed a respiratory epithelial adenomatoid hamartoma.

conclusionThis observation suggests that the presence of hamartomas in polyposis is common, but underdiagnosed. LEVEL OF EVIDENCE: Step 3 (Level 3).

Indexed as

HamartomaNasal PolypsParanasal SinusesCross-Sectional StudiesDiagnosis, DifferentialHumansPrevalenceNasal computed tomography scanNasal polyposisOlfactory cleftREAH, respiratory epithelial adenomatoid hamartoma

Identifiers

PMID34844870
PMCPMC9801022
OpenAlexW3214065611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.