Evidence map›Paper›PMID 34844425›Full record

ArticlemBio2021

The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3.

Uthman Okalang, Bar Mualem Bar-Ner, K Shanmugha Rajan, Nehemya Friedman, Saurav Aryal, Katarina Egarmina, Ronen Hope, Netaly Khazanov, Hanoch Senderowitz, Assaf Alon and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. The endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Uthman Okalang *The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Bar Mualem Bar-Ner *The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
K Shanmugha Rajan *The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Nehemya FriedmanThe Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Saurav AryalThe Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Katarina EgarminaThe Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Ronen HopeThe Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Netaly KhazanovChemistry Department, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Hanoch SenderowitzChemistry Department, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.
Assaf AlonDepartment of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Deborah FassDepartment of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Shulamit MichaeliThe Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan Universitygrid.22098.31, Ramat-Gan, Israel.ORCID 0000-0002-9895-0439
Bar-Ilan University · ILWeizmann Institute of Science · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the parasite Trypanosoma brucei, the causative agent of human African sleeping sickness, all mRNAs are

Indexed as

Cell NucleusEndoplasmic ReticulumGolgi ApparatusHumansMitochondrial ProteinsProtein Serine-Threonine KinasesProtein TransportProtozoan ProteinsRNA InterferenceRNA, ProtozoanRNA, Spliced LeaderRNA SplicingTATA-Box Binding ProteinTrypanosoma brucei bruceiTrypanosomiasis, AfricanMitochondrial ProteinsPK3 protein, Trypanosoma bruceiProtein Serine-Threonine KinasesProtozoan ProteinsRNA, ProtozoanRNA, Spliced LeaderTATA-Box Binding ProteinBiPcalreticulinERO1PK3-PERK homologueQSOXSLSspliced leader RNA silencingTIMRHOM1trypanosomes

Identifiers

PMID34844425
PMCPMC8630539
OpenAlexW3216193358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.