Evidence map›Paper›PMID 34844082›Full record

ArticleVirology2022

Heterogeneous phenotypes of Pten-null hepatocellular carcinoma in hepatitis B virus transgenic mice parallels liver lobule zonal gene expression patterns.

Claudia E Oropeza, Caitlin R Ondracek, Grant Tarnow, Mark Maienschein-Cline, Stefan J Green, Alan McLachlan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Claudia E OropezaDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL, 60612, USA.
Caitlin R OndracekDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL, 60612, USA.
Grant TarnowDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL, 60612, USA.
Mark Maienschein-ClineResearch Resources Center, College of Medicine, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL, 60612, USA.
Stefan J GreenResearch Resources Center, College of Medicine, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL, 60612, USA.
Alan McLachlanDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL, 60612, USA. Electronic address: mclach@uic.edu.
University of Illinois Chicago · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Developmental regulation of HBV biosynthesis by FoxA and DNA methylationR01AI125401 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCLACHLAN, ALAN · 2016 to 2020
$2.0M
Liver lobule zonation, hepatocellular carcinoma (HCC) and β-catenin mediated hepatitis B virus (HBV) biosynthesisR01CA238328 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCLACHLAN, ALAN · 2020 to 2024
$1.8M
NCATS NIH HHS UL1 TR002003NCI NIH HHS R01 CA238328NIAID NIH HHS R01 AI125401
6 · The paper itself

Abstract

Chronic HBV infection is a major cause of hepatocellular carcinoma (HCC) worldwide. The phenotypes of HCC are diverse, in part, due to mutations in distinct oncogenes and/or tumor suppressor genes. These genetic drivers of HCC development have generally been considered as major mediators of tumor heterogeneity. Using the liver-specific Pten-null HBV transgenic mouse model of chronic viral infection, a critical role for liver lobule zone-specific gene expression patterns in determining HCC phenotype and β-catenin-dependent HBV biosynthesis is demonstrated. These observations suggest that the position of the hepatocyte within the liver lobule, and hence its intrinsic gene expression pattern at the time of cellular transformation, make critical contributions to the properties of the resulting liver tumor. These results may explain why therapies targeting pathways modulated by specific identified tumor driver genes display variable treatment efficacy.

Indexed as

Animalsbeta CateninCarcinoma, HepatocellularCell Transformation, NeoplasticFemaleGene Expression Regulation, NeoplasticGenetic HeterogeneityHepatitis BHepatitis B virusHepatocytesHepcidinsHumansIntercellular Signaling Peptides and ProteinsLipocalin-2LiverLiver Neoplasmsbeta CateninCTNNB1 protein, mouseHamp protein, mouseHepcidinsIntercellular Signaling Peptides and ProteinsLcn2 protein, mouseLect2 protein, mouseLipocalin-2Ornithine-Oxo-Acid TransaminasePTEN PhosphohydrolasePten protein, mouseT-Box Domain ProteinsTbx3 protein, mouseHepatitis B virus (HBV)Hepatocellular carcinoma (HCC)Liver lobule zonationPhosphatase and tensin homolog (Pten)β-catenin (Ctnnb1)

Identifiers

PMID34844082
PMCPMC8712409
OpenAlexW3217267282

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.