Evidence map›Paper›PMID 34843826›Full record

ReviewJournal of virological methods2022

The evolving direct and indirect platforms for the detection of SARS-CoV-2.

Sonia Fathi Karkan, Reza Maleki Baladi, Mehdi Shahgolzari, Monireh Gholizadeh, Fahimeh Shayegh, Arash Arashkia

Open access · greenAbstract readReview
In one paragraph

Review in Journal of virological methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

  1. Proteomics in the Diagnosis of Viral and Pathogenic Infections.Advances in experimental medicine and biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sonia Fathi KarkanStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Nanotechnology, Tabriz Medical University, Tabriz, Iran.
Reza Maleki BaladiYoung Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Mehdi ShahgolzariDepartment of Medical Nanotechnology, Tabriz Medical University, Tabriz, Iran.
Monireh GholizadehDepartment of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Pasteur Institute of Iran, Tehran, Iran.
Fahimeh ShayeghDepartment of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Arash ArashkiaDeaprtment of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran. Electronic address: a_arashkia@pasteur.ac.ir.
Tabriz University of Medical Sciences · IRPasteur Institute of Iran · IRIslamic Azad University of Tabriz · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosis of SARS-CoV-2 by standard screening measures can reduce the chance of COVID-19 spread before the symptoms become severe. Detecting viral RNA and antigens, anti-viral antibodies, and CT-scan are the most routine diagnostic methods. Accordingly, several diagnostic platforms including thermal and isothermal amplifications, CRISPR/Cas‑based approaches, digital PCR, ELISA, NGS, and point-of-care testing methods with variable sensitivities, have been developed that may facilitate managing and preventing the further spread of the infection. Here, we summarized the currently available direct and indirect testing platforms in research and clinical settings, including recent progress in the methods to detect viral RNA, antigens, and specific antibodies. This summary may help in selecting the effective method for a special application sucha as routine laboratory diagnosis, point-of-care tests or tracing the the virus spread and mutations.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralClinical Laboratory TechniquesHumansPoint-of-Care TestingAntibodies, ViralCOVID-19Diagnostic methodRT-PCRSARS-CoV-2Serology

Identifiers

PMID34843826
PMCPMC8626143
OpenAlexW3215368675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.