Evidence map›Paper›PMID 34843713›Full record

ArticleJournal of immunological methods2022

Murine monoclonal antibodies against RBD of the SARS-CoV-2 spike protein as useful analytical tools for subunit vaccine development and clinical trials.

Omar R Blanco, Dayamí Dorta, Carlos A Hernández, Daymí Abreu, Andy G Domínguez, Yaramis Luna, Onel Valdivia, Maylín Pérez-Bernal, Celia Tamayo, Gilda Lemos and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunological methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Omar R BlancoCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Dayamí DortaCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Carlos A HernándezCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Daymí AbreuCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Andy G DomínguezCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Yaramis LunaCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Onel ValdiviaCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Maylín Pérez-BernalCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Celia TamayoCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Gilda LemosCenter for Genetic Engineering and Biotechnology, Ave. 31 e/ 158 y 190, Playa, Havana, Cuba.
Ivis M PasarónCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Joel J PérezCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Liudmila BenítezCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Mónica Bequet-RomeroCenter for Genetic Engineering and Biotechnology, Ave. 31 e/ 158 y 190, Playa, Havana, Cuba.
Anitza FragasCivilian Defense Scientific Research Center, Carretera de Jamaica y Autopista 15 Nacional, San José de las Lajas, Mayabeque, Cuba.
Yeosvany CabreraCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba. Electronic address: yeosvany.cabrera@cigb.edu.cu.
Enrique R PérezCenter for Genetic Engineering and Biotechnology of Sancti Spíritus, Circunvalante Norte, Olivos III, Sancti Spíritus, Cuba.
Centro de Ingeniería Genética y Biotecnología · CU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 pandemic poses a serious threat to human health; it has completely disrupted global stability, making vaccine development an important goal to achieve. Monoclonal antibodies play an important role in subunit vaccines strategies. In this work, nine murine MAbs against the RBD of the SARS-CoV-2 spike protein were obtained by hybridoma technology. Characterization of purified antibodies demonstrated that five of them have affinities in the order of 10

Indexed as

Angiotensin-Converting Enzyme 2AnimalsAntibodies, MonoclonalClinical Trials as TopicCOVID-19COVID-19 VaccinesFemaleGenetic EngineeringHumansMiceMice, Inbred BALB CProtein Interaction Domains and MotifsSARS-CoV-2Vaccine DevelopmentVaccines, SubunitAngiotensin-Converting Enzyme 2Antibodies, MonoclonalCOVID-19 VaccinesVaccines, SubunitAdditivity indexCOVID-19Neutralizing monoclonal antibodiesReceptor binding domainSARS-CoV-2

Identifiers

PMID34843713
PMCPMC8619880
OpenAlexW3217530994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.