SynthesisThe Lancet. Respiratory medicine2022
The role of growth and nutrition in the early origins of spirometric restriction in adult life: a longitudinal, multicohort, population-based study.
Synthesis in The Lancet. Respiratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Normal age-related decline in forced vital capacity: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Early-life serum protein profiles associated with bronchopulmonary dysplasia in extremely preterm infants.Respiratory research · 2026Observational
- Association of childhood growth with adult lung function: A prospective urban birth cohort study from India.The Indian journal of medical research · 2026Article
- Maternal and perinatal nutritional programming of lung health and disease in childhood and early adulthood: Research gaps and opportunities-National Heart, Lung, and Blood Institute/National Institutes of Health Workshop Report.The Journal of allergy and clinical immunology · 2026Article
- Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction.Nature communications · 2026Article
- Preserved Ratio Impaired Spirometry in Low- and Middle-Income Countries: An Emerging Cardiopulmonary Phenotype and Cardiovascular Risk-A Narrative Review.Life (Basel, Switzerland) · 2026Review
- The Impact of Small-for-Gestational-Age on Pulmonary Function in Infancy, a Retrospective Cohort Study.Pediatric pulmonology · 2026Article
- The role of CC16 in the associations of preterm birth with lung function and asthma in adult life.The Journal of allergy and clinical immunology · 2026Article
- Body mass index, lung function, and FeNO in children with positive bronchodilator response: a cross-sectional study.Frontiers in pediatrics · 2026Article
- Association of birth weight with lung function and the mediating role of gut microbiota: A STROBE 2-step Mendelian randomization study.Medicine · 2025Article
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- Early Onset Asthma, But Not Aeroallergen Sensitization, Is Associated With Lung Function Impairment in Young Adulthood-A Prospective Cohort Study.Clinical and translational allergy · 2025Article
- The impact of child and adolescent health on adult respiratory health: the evidence, gaps and priorities.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Heterogeneity of reduced FEVRespirology (Carlton, Vic.) · 2025Article
- Preserved ratio impaired spirometry: clinical, imaging and artificial intelligence perspective.Journal of thoracic disease · 2025Review
- Body mass index trajectories from birth to early adulthood and lung function development.The European respiratory journal · 2025Article
- Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population Aged 50-64 Years.Annals of the American Thoracic Society · 2024Article
- Dietary and activity habits associated with hypertension in Kunming school-aged children and adolescents: A multilevel analysis of the study of hypertension risks in children and adolescents.Preventive medicine reports · 2024Article
- Relationships between lung function, allergy, and wheezing in urban children.The Journal of allergy and clinical immunology · 2024Article
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Authors and funding
17 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundSpirometric restriction, defined as a reduced forced vital capacity (FVC) with a preserved FEV
methodsIn this longitudinal, multicohort, population-based study, we used data from the Tucson Children's Respiratory Study (TCRS), which recruited 1246 healthy infants at birth between April 1980, and October 1984, in Tucson, AZ, USA. Questionnaires were answered by the primary caregiver at enrolment, immediately after the child's birth, and multiple follow-up questionnaires were completed through childhood and adulthood. At the age of 22, 26, 32, and 36 years, lung function was measured with spirometry. At each survey, three mutually exclusive spirometric patterns were defined: (1) normal (FEV
findingsOf 1246 healthy infants included in TCRS, for the present study we included data for 652 participants who had at least one set of spirometry data, contributing up to 1668 observations. In the TCRS cohort, results from the multivariate models showed that maternal nutritional problems during pregnancy (RRR 2·48 [95% CI 1·30-4·76]; p=0·0062), being born small for gestational age (birthweight <10th percentile; 3·26 [1·34-7·93]; p=0·0093), and being underweight in childhood (BMI-for-age <5th percentile; 3·54 [1·35-9·26]; p=0·010) were independent predictors of spirometric restriction in adult life. Associations between being small for gestational age (p=0·0028) and underweight in childhood (p<0·0001) with adult spirometric restriction were supported by the results of meta-analysis of data from all three cohorts. In the MAAS cohort, having a low lean BMI (ie, <10th percentile) at age 11 years predicted adult (age 18 years) spirometric restriction (RRR 3·66 [1·48-9·02]; p=0·0048). These associations of spirometric restriction with small for gestational age, childhood underweight, and low lean BMI in childhood were verified in participants with spirometric restriction who had diminished total lung capacity, indicating that these factors specifically increase the risk of lung restriction.
interpretationPoor growth and nutritional deficits in utero and throughout childhood precede and predict the development of spirometric restriction in adult life. Strategies to improve prenatal and childhood growth trajectories could help to prevent spirometric restriction and its associated morbidity and mortality burden.
fundingNational Institutes of Health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.