Evidence map›Paper›PMID 34843656›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy.

James A Votava, Shannon R Reese, Kathryn M Deck, Christopher P Nizzi, Sheila A Anderson, Arjang Djamali, Richard S Eisenstein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

James A VotavaDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin.
Shannon R ReeseDivision of Nephrology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0002-6760-8876
Kathryn M DeckDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0001-5690-906X
Christopher P NizziDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0001-8185-3846
Sheila A AndersonDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin.
Arjang DjamaliDivision of Nephrology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Richard S EisensteinDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0002-8523-2614
University of Wisconsin–Madison · US

Funding

Biological Functions of Iron Responsive ElementsR01DK066600 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI EISENSTEIN, RICHARD S. · 2005 to 2017
$3.4M
NIDDK NIH HHS R01 DK066600
6 · The paper itself

Abstract

Chronic kidney disease involves disturbances in iron metabolism including anemia caused by insufficient erythropoietin (EPO) production. However, underlying mechanisms responsible for the dysregulation of cellular iron metabolism are incompletely defined. Using the unilateral ureteral obstruction (UUO) model in

Indexed as

AnemiaAnimalsBasic Helix-Loop-Helix ProteinsCell HypoxiaDisease Models, AnimalEndothelial PAS Domain-Containing Protein 1ErythropoietinFerritinsFibrosisHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesIronIron Regulatory Protein 1KidneyMaleMiceBasic Helix-Loop-Helix ProteinsEgln1 protein, mouseEndothelial PAS Domain-Containing Protein 1Epo protein, mouseErythropoietinFerritinsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesIronIron Regulatory Protein 1PHD1 protein, mouseProcollagen-Proline DioxygenaseReceptors, TransferrinTfrc protein, mouseerythropoietiniron metabolismiron regulatory proteinsprolyl hydroxylaserenal failure

Identifiers

PMID34843656
PMCPMC8742730
OpenAlexW3217464831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.