Evidence map›Paper›PMID 34843645›Full record

ArticleAnalytical chemistry2021

Fast Quantitative LC-MS/MS Determination of Illicit Substances in Solid and Liquid Unknown Seized Samples.

Giuseppe M Merone, Angela Tartaglia, Sandra Rossi, Francesco Santavenere, Elisa Bassotti, Cristian D'Ovidio, Martina Bonelli, Enrica Rosato, Ugo de Grazia, Marcello Locatelli and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 43 citations in OpenAlex.

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  13. Interpol Review of Drug Analysis 2019-2022.Forensic science international. Synergy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Giuseppe M MeronePharmatoxicology Laboratory, Hospital "Santo Spirito", Via Fonte Romana 8, Pescara 65124, Italy.
Angela TartagliaDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, Chieti 66100, Italy.
Sandra RossiPharmatoxicology Laboratory, Hospital "Santo Spirito", Via Fonte Romana 8, Pescara 65124, Italy.
Francesco SantavenerePharmatoxicology Laboratory, Hospital "Santo Spirito", Via Fonte Romana 8, Pescara 65124, Italy.
Elisa BassottiR&D Department, Eureka Lab Division, Via Enrico Fermi, 25, Chiaravalle 60033, Italy.
Cristian D'OvidioDepartment of Medicine and Aging Sciences, Section of Legal Medicine, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.
Martina BonelliDepartment of Medicine and Aging Sciences, Section of Legal Medicine, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.
Enrica RosatoDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, Chieti 66100, Italy.
Ugo de GraziaLaboratory of Neurological Biochemistry and Neuropharmacology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Marcello LocatelliDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, Chieti 66100, Italy.ORCID 0000-0002-0840-825X
Fabio SaviniPharmatoxicology Laboratory, Hospital "Santo Spirito", Via Fonte Romana 8, Pescara 65124, Italy.
University of Chieti-Pescara · ITOspedale di Santo Spirito · ITFondazione IRCCS Istituto Neurologico Carlo Besta · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Narcotic and psychotropic substances are natural, synthetic, or semisynthetic compounds that are present in both solid and liquid illicit products. The alterations effects on the central nervous system related to their use can be psycholeptic, psychoanaleptic, or psychodiseptic and are able to generate tolerance, addiction, or dependence phenomena, creating social and public order problems. In this scenario, the analytical evaluations that aim to determine these analytes in seized nonbiological samples, and which assume the character of judicial evidence, must meet high analytical requirements of reliability, transparency, and procedures uniformity at a national level. For the first time in the literature, the herein validated method is able to provide the simultaneous quantitative determination of 37 of the most common narcotic substances as well as the most commonly used excipients/adulterants found in seized illicit material. Additionally, the validated method can process both solid and liquid samples maintaining the precision and trueness levels (intraday and interday) in accordance with the U.S. Food and Drug Administration and European Medicines Agency international guidelines (<14.31 and <13.41%, respectively). Furthermore, it provides a simple and fast procedure for sample preparation using the

Indexed as

Specimen HandlingTandem Mass SpectrometryChromatography, LiquidReproducibility of ResultsUnited States

Identifiers

PMID34843645
PMCPMC8674870
OpenAlexW3217753961

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.