ArticlePLoS pathogens2021
Inferring Mycobacterium bovis transmission between cattle and badgers using isolates from the Randomised Badger Culling Trial.
Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 62 citations in OpenAlex.
- Uncovering the genomic landscape of Mycobacterium bovis in Wales.Scientific reports · 2026Article
- Whole-genome sequencing reveals genetic diversity and transmission dynamics ofMicrobial genomics · 2026Article
- A simulation model to predict the most efficient way to utilise operational resources when vaccinating badgers against bTB.PloS one · 2026Article
- Metabolomic changes in the peripheral blood of wild trapped badgers (Meles meles) correlate with bovine tuberculosis (Mycobacterium bovis) infection status.BMC veterinary research · 2025Article
- Data-driven analysis of fine-scale badger movement in the UK.PLoS computational biology · 2025Article
- Enhanced analysis of the genomic diversity ofFrontiers in microbiology · 2025Article
- Whole-Genome sequencing in routineMicrobial genomics · 2024Article
- Genomic comparison betweenFrontiers in veterinary science · 2024Article
- Whole genome sequencing improves the discrimination betweenOne health (Amsterdam, Netherlands) · 2023Article
- Review
- Assessing the impact of a test and vaccinate or remove badger intervention project on bovine tuberculosis levels in cattle herds.Epidemiology and infection · 2023Article
- Analysis of a multi-type resurgence of Mycobacterium bovis in cattle and badgers in Southwest France, 2007-2019.Veterinary research · 2023Article
- Genomic epidemiology ofMicrobial genomics · 2023Article
- Inferring bovine tuberculosis transmission between cattle and badgers via the environment and risk mapping.Frontiers in veterinary science · 2023Article
- Evidence, Challenges, and Knowledge Gaps Regarding Latent Tuberculosis in Animals.Microorganisms · 2022Review
- Disturbance Ecology Meets Bovine Tuberculosis (bTB) Epidemiology: A Before-and-After Study on the Association between Forest Clearfelling and bTB Herd Risk in Cattle Herds.Pathogens (Basel, Switzerland) · 2022Article
- Selective sweep sites and SNP dense regions differentiateFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Mycobacterium bovis (M. bovis) is a causative agent of bovine tuberculosis, a significant source of morbidity and mortality in the global cattle industry. The Randomised Badger Culling Trial was a field experiment carried out between 1998 and 2005 in the South West of England. As part of this trial, M. bovis isolates were collected from contemporaneous and overlapping populations of badgers and cattle within ten defined trial areas. We combined whole genome sequences from 1,442 isolates with location and cattle movement data, identifying transmission clusters and inferred rates and routes of transmission of M. bovis. Most trial areas contained a single transmission cluster that had been established shortly before sampling, often contemporaneous with the expansion of bovine tuberculosis in the 1980s. The estimated rate of transmission from badger to cattle was approximately two times higher than from cattle to badger, and the rate of within-species transmission considerably exceeded these for both species. We identified long distance transmission events linked to cattle movement, recurrence of herd breakdown by infection within the same transmission clusters and superspreader events driven by cattle but not badgers. Overall, our data suggests that the transmission clusters in different parts of South West England that are still evident today were established by long-distance seeding events involving cattle movement, not by recrudescence from a long-established wildlife reservoir. Clusters are maintained primarily by within-species transmission, with less frequent spill-over both from badger to cattle and cattle to badger.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.