Evidence map›Paper›PMID 34843419›Full record

ArticleRNA biology2021

Nucleo-cytoplasmic RNA distribution responsible for maintaining neuroinflammatory microenvironment.

Yuyan Liao, Chenghao Kuang, Zheng Bao, Yijing He, Long Gu, Qianke Tao, Xiancheng Qiu, Ghosh Dipritu, Xi Kong, Lifang Zhang and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yuyan LiaoDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Chenghao KuangLaboratory of Neurological Diseases and Brain Function, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Zheng BaoLaboratory of Neurological Diseases and Brain Function, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Yijing HeLaboratory of Neurological Diseases and Brain Function, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Long GuLaboratory of Neurological Diseases and Brain Function, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Qianke TaoDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Xiancheng QiuDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Ghosh DiprituDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Xi KongLaboratory of Neurological Diseases and Brain Function, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Lifang ZhangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jianhua PengDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Yong JiangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Shigang YinLaboratory of Neurological Diseases and Brain Function, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Affiliated Hospital of Southwest Medical University · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcellular localization of transcripts is highly associated with regulation of gene expression, synthesis of protein, and also the development of the human brain cortex. Although many mechanisms are prevalent in the occurrence of neuroinflammation, the mechanisms based on differences in subcellular localization of transcripts have not been explored. To characterize the dynamic profile of nuclear and cytoplasmic transcripts during the progress of haemorrhage-induced neuroinflammation, we isolated nucleo-cytoplasmic RNA fractions of oxyhaemoglobin (oxy-Hb) treated microglia cells and sequenced both fractions. We discovered that cytoplasmic retained genes were the major forces to maintain the neuroinflammatory microenvironment with 10 hub genes and 40 conserved genes were identified. Moreover, antisense RNA Gm44096 and lincRNA Gm47270, which co-expressed with a crowd of inflammatory genes in the cytoplasm, were discovered as regulatory strategies for sustaining the neuroinflammatory microenvironment. Thus, our study provides a new perspective on understanding haemorrhage-induced neuroinflammation and also reveals a mechanism of lncRNA responsible for maintaining the neuroinflammatory microenvironment.

Indexed as

RNA TransportAnimalsCell LineCell NucleusCellular MicroenvironmentComputational BiologyCytoplasmDisease Models, AnimalDisease SusceptibilityGene Expression ProfilingGene OntologyHemorrhageMiceMicrogliaNeuroinflammatory DiseasesRNA, Long NoncodingRNA, Long NoncodinglncRNAMicroglianeuroinflammationneuroinflammatory microenvironmentsubcellular transcripts localization

Identifiers

PMID34843419
PMCPMC8782176
OpenAlexW3215139128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.