Evidence map›Paper›PMID 34843409›Full record

ArticleAmerican journal of physiology. Renal physiology2022

ROMK channels are inhibited in the aldosterone-sensitive distal nephron of renal tubule Nedd4-2-deficient mice.

Dan-Dan Zhang, Jun-Ya Zheng, Xin-Peng Duan, Dao-Hong Lin, Wen-Hui Wang

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. SARS-CoV-2 N protein induces hypokalemia in acute kidney injury mice via ENaC-dependent mechanism.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  3. Article
  4. Article
  5. Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake.Journal of the American Society of Nephrology : JASN · 2024
    Article
  6. Article
  7. Article
  8. Steroidal or non-steroidal MRAs: should we still enable RAASi use through K binders?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  9. Inwardly rectifying KAmerican journal of physiology. Cell physiology · 2022
    Review
  10. The effect of high-dietary KFrontiers in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Dan-Dan ZhangGuangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.
Jun-Ya ZhengDepartment of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Xin-Peng DuanDepartment of Pharmacology, New York Medical College, Valhalla, New York.ORCID 0000-0003-2251-9607
Dao-Hong LinDepartment of Pharmacology, New York Medical College, Valhalla, New York.ORCID 0000-0003-1760-2684
Wen-Hui WangDepartment of Pharmacology, New York Medical College, Valhalla, New York.ORCID 0000-0002-7503-9554
New York Medical College · USHarbin Medical University · CN

Funding

Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Kir5.1 regulates Kir4.1 ubiquitination by Nedd4-2 in DCTR01DK115366 · NIDDK · NEW YORK MEDICAL COLLEGE · PI LIN, DAO-HONG · 2018 to 2021
$1.5M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR56DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2021 to 2021
$100k
NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R01 DK115366NIDDK NIH HHS R56 DK054983
6 · The paper itself

Abstract

We used whole cell recording to examine the renal outer medullary K

Indexed as

AldosteroneAnimalsDiet, Sodium-RestrictedEpithelial Sodium ChannelsKidney Tubules, DistalMaleMembrane PotentialsMiceMice, KnockoutNedd4 Ubiquitin Protein LigasesPotassium Channels, Inwardly RectifyingPotassium, DietarySodium Chloride, DietaryAldosteroneEpithelial Sodium ChannelsKcnj1 protein, mouseNedd4l protein, mouseNedd4 Ubiquitin Protein LigasesPotassium Channels, Inwardly RectifyingPotassium, DietarySodium Chloride, Dietarycortical collecting ductdistal convoluted tubuleepithelial Na+ channelrenal outer medullary K+ channelwith no lysine kinase 1

Identifiers

PMID34843409
PMCPMC8714254
OpenAlexW3216735944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.