Evidence map›Paper›PMID 34843389›Full record

ArticleAntimicrobial agents and chemotherapy2022

Loss of GdpP Function in Staphylococcus aureus Leads to β-Lactam Tolerance and Enhanced Evolution of β-Lactam Resistance.

Raymond Poon, Li Basuino, Nidhi Satishkumar, Aditi Chatterjee, Nagaraja Mukkayyan, Emma Buggeln, Liusheng Huang, Vinod Nair, Maria A Argudín, Sandip K Datta and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Mislocalization of PBPs inMicrobiology spectrum · 2026
    Article
  2. A c-di-AMP-controlled glutamine synthesis pathway promotes persistence ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
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  5. Review
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  13. Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Review
  15. mSphere · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Raymond Poon *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.
Li Basuino *Division of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Franciscogrid.266102.1, San Francisco, California, USA.
Nidhi SatishkumarDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.
Aditi ChatterjeeDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.
Nagaraja MukkayyanDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.
Emma BuggelnDivision of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Franciscogrid.266102.1, San Francisco, California, USA.
Liusheng HuangDrug Research Unit, Department of Clinical Pharmacy, University of California, San Franciscogrid.266102.1, San Francisco, California, USA.
Vinod NairMicroscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Healthgrid.94365.3d, Hamilton, Montana, USA.
Maria A ArgudínNational Reference Centre for Staphylococcus aureus, Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles Universitair Laboratorium Brussel (LHUB-ULB), Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0003-4026-6447
Sandip K DattaBacterial Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Healthgrid.94365.3d, Bethesda, Maryland, USA.
Henry F ChambersDivision of HIV/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Franciscogrid.266102.1, San Francisco, California, USA.
Som S ChatterjeeDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimoregrid.411024.2, Maryland, USA.ORCID 0000-0002-7138-4449
University of Maryland, Baltimore · USSan Francisco General Hospital · USNational Institutes of Health · USUniversité Libre de Bruxelles · BEUniversity of California, San Francisco · US

Funding

Novel Mechanisms of Beta-lactam Resistance in Staph AureusR01AI100291 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM, HENRY CHAMBERS, HENRY F · 2013 to 2023
$5.1M
Novel mechanism of mecA expression in Staphylococcus aureusR21AI142501 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM · 2019 to 2020
$425k
NIAID NIH HHS R01 AI100291NIAID NIH HHS R21 AI142501
6 · The paper itself

Abstract

Infections caused by Staphylococcus aureus are a leading cause of mortality. Treating infections caused by S. aureus is difficult due to resistance against most traditional antibiotics, including β-lactams. We previously reported the presence of mutations in

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcus aureusAnti-Bacterial AgentsBacterial Proteinsbeta-Lactam Resistancebeta-LactamsDrug ToleranceMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamsbeta-lactamscyclic-di-AMPGdpPStaphylococcus aureustolerance

Identifiers

PMID34843389
PMCPMC8846394
OpenAlexW3215577018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.