Evidence map›Paper›PMID 34843378›Full record

ArticleJournal of bacteriology2022

Drown Them in Their Own Garbage: a New Strategy To Reverse Polymyxin Resistance?

Kerrie L May

Open access · greenAbstract readComment
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kerrie L MayEmory Antibiotic Resistance Center, Emory Universitygrid.189967.8 School of Medicine, Atlanta, Georgia, USA.
Emory University · US

Funding

Lipoprotein trafficking to the bacterial outer membraneR35GM133509 · NIGMS · EMORY UNIVERSITY · PI GRABOWICZ, MARCIN · 2019 to 2023
$1.9M
NIGMS NIH HHS R35 GM133509
6 · The paper itself

Abstract

Purcell and colleagues offer new insights into a major mechanism of polymyxin resistance in Gram-negative bacteria (A. B. Purcell, B. J. Voss, and M. S. Trent, J Bacteriol 204:e00498-21, 2022, https://doi.org/10.1128/JB.00498-21). Inactivating a single lipid recycling enzyme causes accumulation of waste lipid by-products that inhibit a key factor responsible for polymyxin resistance.

Indexed as

ColistinPolymyxinsAnti-Bacterial AgentsGram-Negative BacteriaAnti-Bacterial AgentsColistinPolymyxinsantibiotic resistanceGram-negative bacterialipopolysaccharidemembranesmobile colistin resistancepolymyxins

Identifiers

PMID34843378
PMCPMC8846470
OpenAlexW3215575615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.