Evidence map›Paper›PMID 34843292›Full record

ArticleJournal of abnormal psychology2021

Decreased reward-related brain function prospectively predicts increased substance use.

Corinne P Bart, Robin Nusslock, Tommy H Ng, Madison K Titone, Ann L Carroll, Katherine S F Damme, Christina B Young, Casey C Armstrong, Jason Chein, Lauren B Alloy

Open access · hybridAbstract read
In one paragraph

Article in Journal of abnormal psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Addiction biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Substance use negatively impacts change in reinforcement during the year following substance use treatment.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025
    Article
  11. A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Corinne P BartDepartment of Psychology, Temple University.ORCID 0000-0003-3058-2462
Robin NusslockDepartment of Psychology, Northwestern University.
Tommy H NgDepartment of Psychology, Temple University.
Madison K TitoneDepartment of Psychology, Temple University.
Ann L CarrollDepartment of Psychology, Northwestern University.
Katherine S F DammeDepartment of Psychology, Northwestern University.ORCID 0000-0003-4260-1528
Christina B YoungDepartment of Psychiatry and Behavioral Sciences, Stanford University.ORCID 0000-0001-9535-2137
Casey C ArmstrongDepartment of Psychology, Northwestern University.ORCID 0000-0001-8492-5032
Jason CheinDepartment of Psychology, Temple University.
Lauren B AlloyDepartment of Psychology, Temple University.
Temple University · USStanford University · US

Funding

Risk for Bipolar Disorder: Reward-related Brain Function & Social RhythmsR01MH077908 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2007 to 2017
$5.7M
Integrated Reward-Inflammation Model Of First Onset Of Major Depression In Adolescence SupplementR01MH123473 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH, NUSSLOCK, ROBIN · 2021 to 2025
$3.8M
Integrated Reward-Circadian Rhythm Model of First Onset of Bipolar Spectrum Disorders in Adolescence SupplementR01MH126911 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH, NUSSLOCK, ROBIN · 2021 to 2025
$3.8M
Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of PsychopathologyT32MH126368 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHANKMAN, STEWART AARON, WAKSCHLAG, LAUREN S · 2021 to 2025
$1.4M
NIMH NIH HHS R01 MH077908NIMH NIH HHS R01 MH123473NIMH NIH HHS R01 MH126911NIMH NIH HHS T32 MH126368
6 · The paper itself

Abstract

Substance use and addiction are prominent global health concerns and are associated with abnormalities in reward sensitivity. Reward sensitivity and approach motivation are supported by a fronto-striatal neural circuit including the orbitofrontal cortex (OFC), ventral striatum (VS), and dorsal striatum (DS). Although research highlights abnormalities in reward neural circuitry among individuals with problematic substance use, questions remain about whether such use arises from excessively high, or excessively low, reward sensitivity. This study examined whether reward-related brain function predicted subsequent substance use course. Participants were 79 right-handed individuals (

Indexed as

Substance-Related DisordersVentral StriatumAdultAnticipation, PsychologicalBrainBrain MappingHumansMagnetic Resonance ImagingMotivationRewardYoung Adult

Identifiers

PMID34843292
PMCPMC8634780
OpenAlexW3217229701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.