Evidence map›Paper›PMID 34843176›Full record

ArticleBrain and behavior2022

Genetic effects on educational attainment in Hungary.

Péter P Ujma, Nóra Eszlári, András Millinghoffer, Bence Bruncsics, Dóra Török, Péter Petschner, Péter Antal, Bill Deakin, Gerome Breen, György Bagdy and 1 more

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Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Péter P UjmaInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-7981-3009
Nóra EszláriDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
András MillinghofferNAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.
Bence BruncsicsDepartment of Measurement and Information Systems, Budapest University of Technology and Economics, Budapest, Hungary.
Dóra TörökDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Péter PetschnerDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Péter AntalDepartment of Measurement and Information Systems, Budapest University of Technology and Economics, Budapest, Hungary.
Bill DeakinDivision of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
György BagdyDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Gabriella JuhászDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEducational attainment is a substantially heritable trait, and it has recently been linked to specific genetic variants by genome-wide association studies (GWASs). However, the effects of such genetic variants are expected to vary across environments, including countries and historical eras.

methodsWe used polygenic scores (PGSs) to assess molecular genetic effects on educational attainment in Hungary, a country in the Central Eastern European region where behavioral genetic studies are in general scarce and molecular genetic studies of educational attainment have not been previously published.

resultsWe found that the PGS is significantly associated with the attainment of a college degree as well as the number of years in education in a sample of Hungarian study participants (N = 829). PGS effect sizes were not significantly different when compared to an English (N = 976) comparison sample with identical measurement protocols. In line with previous Estonian findings, we found higher PGS effect sizes in Hungarian, but not in English participants who attended higher education after the fall of Communism, although we lacked statistical power for this effect to reach significance. DISCUSSION: Our results provide evidence that polygenic scores for educational attainment have predictive value in culturally diverse European populations.

Indexed as

Genome-Wide Association StudyMultifactorial InheritanceEducational StatusHumansHungarycognitive abilitiesgene-environment interactionheritabilitypolygenic scoresocioeconomic status

Identifiers

PMID34843176
PMCPMC8785634

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.