Evidence map›Paper›PMID 34843004›Full record

ArticleNeurochemical research2022

miR-223 Enhances the Neuroprotection of Estradiol Against Oxidative Stress Injury by Inhibiting the FOXO3/TXNIP Axis.

Qiong Pan, Jiezhi Ma, Ke Guo

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  12. Frontiers in molecular neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Qiong PanDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Jiezhi MaDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Ke GuoDepartment of Neurology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China. docgk1979@163.com.
Third Xiangya Hospital · CNCentral South University · CN

Funding

Natural Science Foundation of Hunan Province 2019JJ50912Science and Technology Plan Project of Changsha City, China kq2004142
6 · The paper itself

Abstract

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by complex pathogenesis, of which oxidative stress has long been regarded as a major mechanism. Previously, the protective effects of estradiol on SH-SY5Y cells against Aβ42-induced injuries were demonstrated. In this study, the protection of SH-SY5Y cells by estradiol from H

Indexed as

MicroRNAsNeuroblastomaAnimalsApoptosisCarrier ProteinsEstradiolForkhead Box Protein O3HumansHydrogen PeroxideMiceNeuroprotectionOxidative StressReactive Oxygen SpeciesThioredoxinsCarrier ProteinsEstradiolForkhead Box Protein O3FOXO3 protein, humanHydrogen PeroxideMicroRNAsMIR223, humanMIRN223 microRNA, mouseReactive Oxygen SpeciesThioredoxinsTXNIP protein, humanTxnip protein, mouseEstradiolFOXO3miR-223NeuroprotectionTXNIP

Identifiers

PMID34843004
OpenAlexW3217548664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.