Evidence map›Paper›PMID 34842969›Full record

ArticleAmino acids2022

Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues.

Suzane Rosa da Silva, Predrag Kalaba, Anna Fabišiková, Martin Zehl, Vladimir Dragačević, Luana Ribeiro Dos Anjos, Philip John Neill, Marcus Wieder, Alexander Prado-Roller, Natalie Gajic and 5 more

Open access · greenAbstract read
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In one paragraph

Article in Amino acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Suzane Rosa da SilvaLaboratory of Fine Organic Chemistry, Department of Chemistry and Biochemistry, Faculty of Sciences and Technology of São Paulo State University, Presidente Prudente, São Paulo, 19060-900, Brazil.
Predrag KalabaDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Anna FabišikováMass Spectrometry Centre, Faculty of Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.
Martin ZehlMass Spectrometry Centre, Faculty of Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.
Vladimir DragačevićDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Luana Ribeiro Dos AnjosLaboratory of Fine Organic Chemistry, Department of Chemistry and Biochemistry, Faculty of Sciences and Technology of São Paulo State University, Presidente Prudente, São Paulo, 19060-900, Brazil.
Philip John NeillDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Marcus WiederDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Alexander Prado-RollerCentre for X-Ray Structure Analysis at Faculty of Chemistry, University of Vienna, Währinger Straße 40-42, 1090, Vienna, Austria.
Natalie GajicCentre for X-Ray Structure Analysis at Faculty of Chemistry, University of Vienna, Währinger Straße 40-42, 1090, Vienna, Austria.
Vinicius PalarettiDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14040-901, Brazil.
Gil Valdo Jose da SilvaDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14040-901, Brazil.
Christian PiflDepartment of Molecular Neurosciences, Centre for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria.
Gert LubecDepartment of Neuroproteomics, Paracelsus Medical University, 5020, Salzburg, Austria. gert.lubec@lubeclab.com.
Eduardo R Perez GonzalezLaboratory of Fine Organic Chemistry, Department of Chemistry and Biochemistry, Faculty of Sciences and Technology of São Paulo State University, Presidente Prudente, São Paulo, 19060-900, Brazil. eduardo.gonzalez@unesp.br.ORCID http://orcid.org/0000-0003-1348-8554
University of Vienna · ATUniversidade de Ribeirão Preto · BRUniversidade do Oeste Paulista · BRMedical University of Vienna · ATParacelsus Medical University · ATUniversidade Estadual Paulista (Unesp) · BR

Funding

FAPESP 2016/10149-0
6 · The paper itself

Abstract

Dopamine is an important neurotransmitter that regulates numerous essential functions, including cognition and voluntary movement. As such, it serves as an important scaffold for synthesis of novel analogues as part of drug development effort to obtain drugs for treatment of neurodegenerative diseases, such as Parkinson's disease. To that end, similarity search of the ZINC database based on two known dopamine-1 receptor (D1R) agonists, dihydrexidine (DHX) and SKF 38393, respectively, was used to predict novel chemical entities with potential binding to D1R. Three compounds that showed the highest similarity index were selected for synthesis and bioactivity profiling. All main synthesis products as well as the isolated intermediates, were properly characterized. The physico-chemical analyses were performed using HRESIMS, GC/MS, LC/MS with UV-Vis detection, and FTIR,

Indexed as

CatecholaminesReceptors, Dopamine D12,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepinePhenanthridines2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineCatecholaminesdihydrexidinePhenanthridinesReceptors, Dopamine D1D1R agonistsD2R and DATDihydrexidineDopamine analogsSKF 38393

Identifiers

PMID34842969
OpenAlexW3216293823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.