Evidence map›Paper›PMID 34842946›Full record

ArticleNeuroradiology2022

Incidental findings on 3 T neuroimaging: cross-sectional observations from the population-based Rhineland Study.

Valerie Lohner, Ran Lu, Simon J Enkirch, Tony Stöcker, Elke Hattingen, Monique M B Breteler

Erratum issuedAbstract read
In one paragraph

Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Valerie LohnerPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0001-5589-9701
Ran LuPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-7237-3362
Simon J EnkirchClinic for Neuroradiology, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-5819-0308
Tony StöckerMR Physics, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-8946-9141
Elke HattingenClinic for Neuroradiology, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8392-9004
Monique M B BretelerPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany. Monique.Breteler@dzne.de.ORCID http://orcid.org/0000-0002-0626-9305

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDevelopment of best practices for dealing with incidental findings on neuroimaging requires insight in their frequency and clinical relevance.

methodsHere, we delineate prevalence estimates with 95% confidence intervals and clinical management of incidental findings, based on the first 3589 participants of the population-based Rhineland Study (age range 30-95 years) who underwent 3 Tesla structural neuroimaging (3D, 0.8 mm

resultsOf 3589 participants (mean age 55 ± 14 years, 2072 women), 867 had at least one possible incidental finding (24.2%). Most common were pituitary abnormalities (12.3%), arachnoid cysts (4.1%), developmental venous anomalies (2.5%), non-acute infarcts (1.8%), cavernomas (1.0%), and meningiomas (0.7%). Forty-six participants were informed about their findings, which was hitherto unknown in 40 of them (1.1%). Of these, in 19 participants (48%), a wait-and-see policy was applied and nine (23%) received treatment, while lesions in the remainder were benign, could not be confirmed, or the participant refused to inform us about their clinical diagnosis.

conclusionNearly one-quarter of participants had an incidental finding, but only 5% of those required referral, that mostly remained without direct clinical consequences.

Indexed as

Incidental FindingsMeningeal NeoplasmsAdultAgedAged, 80 and overBrainCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingIncidental findingsMRINeuroimagingObservational studyPopulation-based study

Identifiers

PMID34842946
PMCPMC8850254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.