Evidence map›Paper›PMID 34842756›Full record

ArticleJournal of functional biomaterials2021

Physically Crosslinked Chitosan/PVA Hydrogels Containing Honey and Allantoin with Long-Term Biocompatibility for Skin Wound Repair: An In Vitro and In Vivo Study.

Mojtaba Koosha, Hadis Aalipour, Mohammad Javad Sarraf Shirazi, Ali Jebali, Hong Chi, Sepideh Hamedi, Nianxing Wang, Tianduo Li, Hamideh Moravvej

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mojtaba KooshaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.ORCID 0000-0002-3502-9140
Hadis AalipourChemical and Polymer Engineering Group, Faculty of Engineering, Yazd University, Yazd 8915818411, Iran.
Mohammad Javad Sarraf ShiraziChemical and Polymer Engineering Group, Faculty of Engineering, Yazd University, Yazd 8915818411, Iran.
Ali JebaliDepartment of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd 8916978477, Iran.
Hong ChiShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Sepideh HamediFaculty of New Technologies Engineering, Shahid Beheshti University, Tehran 1983969411, Iran.
Nianxing WangShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Tianduo LiShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.ORCID 0000-0002-6875-1279
Hamideh MoravvejSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chitosan/PVA hydrogel films crosslinked by the freeze-thaw method and containing honey and allantoin were prepared for application as wound dressing materials. The effects of the freeze-thaw process and the addition of honey and allantoin on the swelling, the gel content and the mechanical properties of the samples were evaluated. The physicochemical properties of the samples, with and without the freeze-thaw process, were compared using FTIR, DSC and XRD. The results showed that the freeze-thaw process can increase the crystallinity and thermal stability of chitosan/PVA films. The freeze-thaw process increased the gel content but did not have a significant effect on the tensile strength. The presence of honey reduced the swelling and the tensile strength of the hydrogels due to hydrogen bonding interactions with PVA and chitosan chains. Long-term cell culture experiments using normal human dermal fibroblast (NHDF) cells showed that the hydrogels maintained their biocompatibility, and the cells showed extended morphology on the surface of the hydrogels for more than 30 days. The presence of honey significantly increased the biocompatibility of the hydrogels. The release of allantoin from the hydrogel was studied and, according to the Korsmeyer-Peppas and Weibull models, the mechanism was mainly diffusional. The results for the antimicrobial activity against

Indexed as

allantoinchitosanfreeze–thawhoneypolyvinyl alcoholwound dressing

Identifiers

PMID34842756
PMCPMC8628993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.